ArticleScientific reports2020
In-vivo anterior segment OCT imaging provides unique insight into cerulean blue-dot opacities and cataracts in Down syndrome.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 11 citations in OpenAlex.
- Advancement of cataract classification with artificial intelligence using anterior segment optical coherence tomography images with self-supervised vision transformer.Japanese journal of ophthalmology · 2026Article
- Investigating the eye in Down syndrome as a window to Alzheimer's disease: the REVEAL protocol - a clinical cross-sectional study.BMJ open · 2025Article
- Prevalence of ophthalmic abnormalities and refractive changes in Taiwanese children with Down syndrome.PloS one · 2025Article
- The Ocular Manifestations of Individuals With Down Syndrome: A Systematic Review and Meta-Analysis.Journal of ophthalmology · 2025Review
- Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis.Journal of biomedical science · 2023Article
- Alzheimer's disease amyloid-β pathology in the lens of the eye.Experimental eye research · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
Down syndrome (DS) is frequently associated with cataract, but there remains scant information about DS cataract morphology. Supra-nuclear cataracts in DS have been proposed as indicative of beta-amyloid (Aβ) aggregation and thus potential biomarkers for Alzheimer's (AD). This study employed anterior segment OCT (AS-OCT) and slit-lamp (SL) photography to image the crystalline lens in DS, compared with adult controls. Lens images were obtained post-dilation. Using MATLAB, AS-OCT images were analysed and lens opacities calculated as pixel intensity and area ratios. SL images were classified using LOCS III. Subjects were n = 28 DS (mean ± SD 24.1 ± 14.3years), and n = 36 controls (54.0 ± 3.4years). For the DS group, AS-OCT imaging revealed the frequent presence of small dot opacities (27 eyes, 50%) in the cortex and nucleus of the lens, covering an area ranging from 0.2-14%. There was no relation with age or visual acuity and these dot opacities (p > 0.5) and they were not present in any control lenses. However, their location and morphology does not coincide with previous reports linking these opacities with Aβ accumulation and AD. Four participants (14%) in the DS group had clinically significant age-related cataracts, but there was no evidence of early onset of age-related cataracts in DS.
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