ArticleScientific reports2020
Carbon nanoparticles induce endoplasmic reticulum stress around blood vessels with accumulation of misfolded proteins in the developing brain of offspring.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Nanosystems Containing Proteins: From Fundamentals to Applications.Chemistry, an Asian journal · 2026Review
- Border-associated macrophages: an emerging perspective from physiological basis and multi-disease roles to the mechanism of vascular cognitive impairment and dementia.Journal of neuroinflammation · 2025Review
- Environmental adversity, endoplasmic reticulum stress, and neurogenesis.Neurotoxicology · 2025Review
- Association between Prenatal Particulate Matter Exposure and Neuropsychiatric Disorders Development.Biomolecules & therapeutics · 2025Review
- Changes in the Protein Secondary Structure on the Surface of Silica Nanoparticles with Different Sizes.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review.Small science · 2025Review
- Assessing cytotoxicity and endoplasmic reticulum stress in human blood-brain barrier cells due to silver and copper oxide nanoparticles.Journal of applied genetics · 2025Article
- PM2.5 Exposure Triggers Hypothalamic Oxidative and ER Stress Leading to Depressive-like Behaviors in Rats.International journal of molecular sciences · 2024Article
- Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function.Nature nanotechnology · 2024Article
- Air pollution, glymphatic impairment, and Alzheimer's disease.Trends in neurosciences · 2023Review
- Infrared spectroscopy analysis determining secondary structure change in albumin by cerium oxide nanoparticles.Frontiers in toxicology · 2023Article
- Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling.Particle and fibre toxicology · 2022Article
- Engineered Nanoparticle-Protein Interactions Influence Protein Structural Integrity and Biological Significance.Nanomaterials (Basel, Switzerland) · 2022Review
- The pathogenic effects of particulate matter on neurodegeneration: a review.Journal of biomedical science · 2022Review
- Environmental Nanoparticles Reach Human Fetal Brains.Biomedicines · 2022Article
- A Novel Staining Method for Detection of Brain Perivascular Injuries Induced by Nanoparticle: Periodic Acid-Schiff and Immunohistochemical Double-Staining.Frontiers in toxicology · 2022Article
- Common Fatal Neurodegenerative Diseases Revisited: Beyond Age, Comorbidities, and Devastating Terminal Neuropathology There Is Hope With Prevention.Frontiers in neurology · 2022Article
- Meta-analyses of maternal exposure to atmospheric particulate matter and risk of congenital anomalies in offspring.Environmental science and pollution research international · 2021Review
- Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors.Frontiers in aging neuroscience · 2021Article
- Effect of Carbon Black Nanoparticle on Neonatal Lymphoid Tissues Depending on the Gestational Period of Exposure in Mice.Frontiers in toxicology · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nano-particulate air pollution threatens developing brains and is epidemiologically related to neurodegenerative diseases involving deposition of misfolded proteins. However, the mechanism underlying developmental neurotoxicity by nanoparticles remains unknown. Here, we report that maternal exposure to low doses of carbon black nanoparticle (CB-NP) induces endoplasmic reticulum (ER) stress associated with accumulation of misfolded proteins. Notably, offspring specifically showed high induction of ER stress in perivascular macrophages and reactive astrocytes only around brain blood vessels, along with accumulation of β-sheet-rich proteins regarded as misfolded proteins. Our results suggest that maternal CB-NP exposure induced ER stress in PVMs and reactive astrocytes around blood vessels in the brain of offspring in mice. The induction of ER stress accompanied by the perivascular accumulation of misfolded proteins is likely to be associated with perivascular abnormalities and neurodegeneration, and development of neurodegenerative diseases related to particulate air pollution.
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