Evidence map›Paper›PMID 32572041›Full record

ArticleScientific reports2020

Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery.

Asahi Tomitaka, Hamed Arami, Arash Ahmadivand, Nezih Pala, Anthony J McGoron, Yasushi Takemura, Marcelo Febo, Madhavan Nair

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Review
  19. Advances in Plasmonic Sensing at the NIR-A Review.Sensors (Basel, Switzerland) · 2021
    Review
  20. Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals.Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Asahi TomitakaDepartment of Immunology and Nano-Medicine, Institute of NeuroImmune Pharmacology, Centre for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA.
Hamed AramiMolecular Imaging Program at Stanford (MIPS), The James H Clark Center, Stanford University, Stanford, California, 94305, USA.
Arash AhmadivandDepartment of Electrical and Computer Engineering, Rice University, Houston, Texas, 77005, USA.
Nezih PalaDepartment of Electrical and Computer Engineering, Florida International University, Miami, Florida, 33174, USA.
Anthony J McGoronDepartment of Biomedical Engineering, Florida International University, Miami, Florida, 33174, USA.
Yasushi TakemuraDepartment of Electrical and Computer Engineering, Yokohama National University, Yokohama, 240-8501, Japan.
Marcelo FeboDepartment of Psychiatry, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, 32611, USA.
Madhavan NairDepartment of Immunology and Nano-Medicine, Institute of NeuroImmune Pharmacology, Centre for Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, 33199, USA. nairm@fiu.edu.

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Rana Chakraborty · 2007 to 2026
$33.8M
STANFORD CANCER IMAGING TRAINING (SCIT) PROGRAMT32CA009695 · NCI · STANFORD UNIVERSITY · PI BRUCE L DANIEL, Jeremy Dahl · 1993 to 2026
$7.7M
Nanotechnology Based Gene Editing to Eradicate HIV Brain Reservoir in Drug AbusersR01DA042706 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI KHALILI, KAMEL, NAIR, MADHAVAN P. · 2016 to 2020
$3.2M
To evaluate the role of cannabinoid signaling during the comorbidity of HIV and Alzheimer¿s disease in the context of HIV-associated cognitive disordersR01DA040537 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2015 to 2019
$3.0M
Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2R01DA034547 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2013 to 2018
$1.8M
Multifunctional Nanocarrier to Eradicate HIV from latently infected CNS cells andR01DA037838 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2014 to 2018
$1.8M
Magnetic Particle Imaging (MPI) for Imaging and Magnetothermal Therapy of Brain TumorsK99CA234208 · NCI · STANFORD UNIVERSITY · PI ARAMI, HAMED · 2020 to 2022
$477k
NCI NIH HHS K99 CA234208NCI NIH HHS T32 CA009695NIAID NIH HHS P30 AI073961NIDA NIH HHS R01 DA034547NIDA NIH HHS R01 DA037838NIDA NIH HHS R01 DA040537NIDA NIH HHS R01 DA042706
6 · The paper itself

Abstract

Smart multifunctional nanoparticles with magnetic and plasmonic properties assembled on a single nanoplatform are promising for various biomedical applications. Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine.

Indexed as

AnimalsDrug Delivery SystemsDrug LiberationElectromagnetic PhenomenaFerric CompoundsGoldHumansMagnetic Resonance ImagingMagneticsMagnetite NanoparticlesMultifunctional NanoparticlesMultimodal ImagingPhototherapyPrecision MedicineFerric Compoundsferric oxideGoldMagnetite Nanoparticles

Identifiers

PMID32572041
PMCPMC7308341

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.