ArticleProceedings of the National Academy of Sciences of the United States of America2020
Acoustic trapping of microbubbles in complex environments and controlled payload release.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Acoustically driven micro/nanobubbles: from fundamental mechanisms to biomedical applications.Microsystems & nanoengineering · 2026Review
- Passive Metasurface Tweezers for Multi-Scale Orbital Transport and Trapping on Elastic Plates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Acoustic resonators as wireless actuators in air for small-scale robots.Science advances · 2026Article
- Article
- Space-time acoustofluidic tweezers for dynamic and selective manipulation of microparticles.Science advances · 2026Article
- Hydrogel metapad with ultrasound transparency and broadband focusing for biomedical imaging.National science review · 2026Article
- Synergistic sonothrombolysis based on coaxial confocal dual-frequency focused ultrasound and vortex beams.Ultrasonics sonochemistry · 2025Article
- Oscillating microbubble array-based metamaterials (OMAMs) for rapid isolation of high-purity exosomes.Science advances · 2025Article
- Ultrasound-cavitation-enhanced drug delivery via microbubble clustering induced by acoustic vortex tweezers.Ultrasonics sonochemistry · 2025Article
- Acoustofluidic tweezers via ring resonance.Science advances · 2024Article
- Airborne Acoustic Vortex End Effector-based Contactless, Multi-mode, Programmable Control of Object Surfing.Advanced materials technologies · 2024Article
- Capillary wave tweezer.Scientific reports · 2024Article
- Ultra-stable nano-micro bubbles in a biocompatible medium for safe delivery of anti-cancer drugs.Scientific reports · 2024Article
- Wave-momentum shaping for moving objects in heterogeneous and dynamic media.Nature physics · 2024Article
- Acoustic microbubble propulsion, train-like assembly and cargo transport.Nature communications · 2023Article
- Review of Ultrasonic Particle Manipulation Techniques: Applications and Research Advances.Micromachines · 2023Review
- Phase holograms for the three-dimensional patterning of unconstrained microparticles.Scientific reports · 2023Article
- Near-infrared-laser-navigated dancing bubble within water via a thermally conductive interface.Nature communications · 2022Article
- A sound approach to advancing healthcare systems: the future of biomedical acoustics.Nature communications · 2022Review
- Ultrasound-Responsive Systems as Components for Smart Materials.Chemical reviews · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contactless manipulation of microparticles using acoustic waves holds promise for applications ranging from cell sorting to three-dimensional (3D) printing and tissue engineering. However, the unique potential of acoustic trapping to be applied in biomedical settings remains largely untapped. In particular, the main advantage of acoustic trapping over optical trapping, namely the ability of sound to propagate through thick and opaque media, has not yet been exploited in full. Here we demonstrate experimentally the use of the recently developed technique of single-beam acoustical tweezers to trap microbubbles, an important class of biomedically relevant microparticles. We show that the region of vanishing pressure of a propagating vortex beam can confine a microbubble by forcing low-amplitude, nonspherical, shape oscillations, enabling its full 3D positioning. Our interpretation is validated by the absolute calibration of the acoustic trapping force and the direct spatial mapping of isolated bubble echos, for which both find excellent agreement with our theoretical model. Furthermore, we prove the stability of the trap through centimeter-thick layers of bio-mimicking, elastic materials. Finally, we demonstrate the simultaneous trapping of nanoparticle-loaded microbubbles and activation with an independent acoustic field to trigger the release of the nanoparticles. Overall, using exclusively acoustic powering to position and actuate microbubbles paves the way toward controlled delivery of drug payloads in confined, hard-to-reach locations, with potential in vivo applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.