Evidence map›Paper›PMID 32571912›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection.

Ma Junaliah Tuazon Kels, Esther Ng, Zahrah Al Rumaih, Pratikshya Pandey, Sigrid R Ruuls, Heinrich Korner, Timothy P Newsome, Geeta Chaudhri, Gunasegaran Karupiah

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Article
  8. Article
  9. Article
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  12. Natural Immunomodulatory Agents as a Complementary Therapy for Poxviruses.Advances in experimental medicine and biology · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Article
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  18. Article
  19. Targeting ectromelia virus and TNF/NF-κB or STAT3 signaling for effective treatment of viral pneumonia.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ma Junaliah Tuazon KelsInfection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.ORCID 0000-0002-8730-1062
Esther NgInfection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Zahrah Al RumaihInfection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.ORCID 0000-0002-6317-7749
Pratikshya PandeyViral Immunology and Immunopathology Group, Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.ORCID 0000-0003-4478-7581
Sigrid R RuulsGenmab, 3584 CT Utrecht, The Netherlands.
Heinrich KornerMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Timothy P NewsomeSchool of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Geeta ChaudhriInfection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.ORCID 0000-0003-3388-2102
Gunasegaran KarupiahInfection and Immunity Group, Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia; Guna.Karupiah@utas.edu.au.ORCID 0000-0001-6306-4405
Australian National University · AUUniversity of Tasmania · AUGenmab (Netherlands) · NLThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive tumor necrosis factor (TNF) is known to cause significant pathology. Paradoxically, deficiency in TNF (TNF

Indexed as

AnimalsCell Line, TumorCytokinesFemaleInterferon-gammaInterleukin-10Interleukin-6MiceMice, Inbred C57BLMice, KnockoutPoxviridaePoxviridae InfectionsRespiratory Tract InfectionsSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinTransforming Growth Factor betaCytokinesInterferon-gammaInterleukin-10Interleukin-6Socs3 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinTransforming Growth Factor betaTumor Necrosis Factor-alphadysregulated cytokine responselung inflammation and pathologyrespiratory poxvirus infectionSTAT3 dysregulationtumor necrosis factor deficiency

Identifiers

PMID32571912
PMCPMC7354936
OpenAlexW3036521213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.