ArticleProceedings of the National Academy of Sciences of the United States of America2020
A basal ganglia-like cortical-amygdalar-hypothalamic network mediates feeding behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Sustained hyperactivity of parasubthalamic nucleus by PACAP signaling mediates stress-induced anxiety.Molecular psychiatry · 2026Article
- Associations between thyroid hormones and biochemical metabolism in major depressive disorder patients with and without comorbid eating disorders.Eating and weight disorders : EWD · 2026Article
- Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence.bioRxiv : the preprint server for biology · 2026Article
- Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Whole-Brain Monosynaptic Inputs to Parasubthalamic Calretinin Neurons in Mice.Molecular neurobiology · 2025Article
- A noncanonical parasubthalamic nucleus-to-extended amygdala circuit converts chronic social stress into anxiety.The Journal of clinical investigation · 2025Article
- A genetically defined pontine nucleus essential for ingestion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Tachykinin-1-expressing parasubthalamic nucleus neurons are necessary for odorant-induced appetite suppression.Physiology & behavior · 2025Article
- The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking.Molecular psychiatry · 2025Article
- Topographic organization of bidirectional connections between the cingulate region (infralimbic area and anterior cingulate area, dorsal part) and the interbrain (diencephalon) of the adult male rat.bioRxiv : the preprint server for biology · 2024Article
- Neural circuits regulation of satiation.Appetite · 2024Review
- Mouse parasubthalamicbioRxiv : the preprint server for biology · 2024Article
- Dietary linoleic acid supplementation protects against obesity-induced microglial reactivity in mice.Scientific reports · 2024Article
- A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety.Nature neuroscience · 2024Article
- Deep-Brain Subthalamic Nucleus Stimulation Enhances Food-Related Motivation by Influencing Neuroinflammation and Anxiety Levels in a Rat Model of Early-Stage Parkinson's Disease.International journal of molecular sciences · 2023Article
- Article
- The role of genetically distinct central amygdala neurons in appetitive and aversive responding assayed with a novel dual valence operant conditioning paradigm.bioRxiv : the preprint server for biology · 2023Article
- Dissection of insular cortex layer 5 reveals two sublayers with opposing modulatory roles in appetitive drinking behavior.iScience · 2023Article
- Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice.Nature communications · 2023Article
- Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.Nature communications · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insular cortex (INS) is extensively connected to the central nucleus of the amygdala (CEA), and both regions send convergent projections into the caudal lateral hypothalamus (LHA) encompassing the parasubthalamic nucleus (PSTN). However, the organization of the network between these structures has not been clearly delineated in the literature, although there has been an upsurge in functional studies related to these structures, especially with regard to the cognitive and psychopathological control of feeding. We conducted tract-tracing experiments from the INS and observed a pathway to the PSTN region that runs parallel to the canonical hyperdirect pathway from the isocortex to the subthalamic nucleus (STN) adjacent to the PSTN. In addition, an indirect pathway with a relay in the central amygdala was also observed that is similar in its structure to the classic indirect pathway of the basal ganglia that also targets the STN. C-Fos experiments showed that the PSTN complex reacts to neophobia and sickness induced by lipopolysaccharide or cisplatin. Chemogenetic (designer receptors exclusively activated by designer drugs [DREADD]) inhibition of tachykininergic neurons (Tac1) in the PSTN revealed that this nucleus gates a stop "no-eat" signal to refrain from feeding when the animal is subjected to sickness or exposed to a previously unknown source of food. Therefore, our anatomical findings in rats and mice indicate that the INS-PSTN network is organized in a similar manner as the hyperdirect and indirect basal ganglia circuitry. Functionally, the PSTN is involved in gating feeding behavior, which is conceptually homologous to the motor no-go response of the adjacent STN.
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