Evidence map›Paper›PMID 32571908›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Pervasive changes of mRNA splicing in

Divine-Fondzenyuy Lawir, Katarzyna Sikora, Connor P O'Meara, Michael Schorpp, Thomas Boehm

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Divine-Fondzenyuy LawirDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.
Katarzyna SikoraDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.ORCID 0000-0002-4523-3524
Connor P O'MearaDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.ORCID 0000-0002-2007-8126
Michael SchorppDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.ORCID 0000-0003-2067-2480
Thomas BoehmDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany boehm@ie-freiburg.mpg.de.
Max Planck Institute of Immunobiology and Epigenetics · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcriptome of eukaryotic cells is constantly monitored for errors to avoid the production of undesired protein variants. The evolutionarily conserved nonsense-mediated mRNA decay (NMD) pathway degrades aberrant mRNAs, but also functions in the regulation of transcript abundance in response to changed physiological states. Here, we describe a zebrafish mutant of

Indexed as

AnimalsCodon, NonsenseFertilizationGene Expression Regulation, DevelopmentalGlutathioneHomozygoteHumansNonsense Mediated mRNA DecayRNA-Binding ProteinsRNA, MessengerRNA SplicingT-LymphocytesTranscription FactorsTranscriptomeZebrafishZebrafish Proteins4-methoxy-1-tyrosyl-gamma-glutamyl-cysteinyl-glycineCodon, NonsenseGlutathioneRNA-Binding ProteinsRNA, MessengerRpl10a protein, zebrafishTranscription FactorsZebrafish ProteinsevolutionNMDribosomal proteinthymus

Identifiers

PMID32571908
PMCPMC7354994
OpenAlexW3036185648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.