Evidence map›Paper›PMID 32571881›Full record

ArticleThe Journal of biological chemistry2020

MtcB, a member of the MttB superfamily from the human gut acetogen

Duncan J Kountz, Edward J Behrman, Liwen Zhang, Joseph A Krzycki

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. The living medicine inside us:Gut microbes reports · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Allyl Aryl Ether Cleavage byMicrobiology spectrum · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Isolation and characterization of a novel choline degradingCurrent research in microbial sciences · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Duncan J KountzDepartment of Microbiology, Ohio State University, Columbus, Ohio, USA.
Edward J BehrmanDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.
Liwen ZhangCampus Chemical Instrument Center Mass Spectrometry and Proteomics Facility, Ohio State University, Columbus, Ohio, USA.
Joseph A KrzyckiDepartment of Microbiology, Ohio State University, Columbus, Ohio, USA; Ohio State Biochemistry Program, Ohio State University, Columbus, Ohio, USA. Electronic address: Krzycki.1@osu.edu.
The Ohio State University · US

Funding

Alternative routes of gut microbial methylamine metabolism that may limit trimethylamine N-oxide, a trigger for atherosclerosis.R01DK109345 · NIDDK · OHIO STATE UNIVERSITY · PI KRZYCKI, JOSEPH ADRIAN · 2016 to 2020
$2.2M
Acquisition of a Next Generation Orbitrap MSS10OD018056 · OD · OHIO STATE UNIVERSITY · PI FREITAS, MICHAEL A. · 2014 to 2014
$573k
NIDDK NIH HHS R01 DK109345NIH HHS S10 OD018056
6 · The paper itself

Abstract

The trimethylamine methyltransferase MttB is the first described member of a superfamily comprising thousands of microbial proteins. Most members of the MttB superfamily are encoded by genes that lack the codon for pyrrolysine characteristic of trimethylamine methyltransferases, raising questions about the activities of these proteins. The superfamily member MtcB is found in the human intestinal isolate

Indexed as

Gastrointestinal MicrobiomeBacterial ProteinsEubacteriumHumansMethyltransferasesVitamin B 12Bacterial ProteinsMethyltransferasesVitamin B 12acetogenesisbacterial metabolismcarnitinecobalaminenergy metabolismenzyme catalysisfolatemicrobiologymicrobiomeone-carbon metabolism

Identifiers

PMID32571881
PMCPMC7443480
OpenAlexW3036869639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.