Evidence map›Paper›PMID 32571876›Full record

ArticleThe Journal of biological chemistry2020

5'-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs.

Solomon A Haizel, Usha Bhardwaj, Ruben L Gonzalez, Somdeb Mitra, Dixie J Goss

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 52 citations in OpenAlex.

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  7. mRNA-based therapeutic strategies for cancer treatment.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
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  16. The mechanism of mRNA activation.bioRxiv : the preprint server for biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Solomon A HaizelPh.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, New York, USA.
Usha BhardwajDepartment of Chemistry, Hunter College, New York, New York, USA.
Ruben L GonzalezDepartment of Chemistry, Columbia University, New York, New York, USA.ORCID 0000-0002-1344-5581
Somdeb MitraDepartment of Chemistry, New York University, New York, New York, USA.
Dixie J GossPh.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, New York, USA dgoss@hunter.cuny.edu.ORCID 0000-0002-8500-0629
The Graduate Center, CUNY · USColumbia University · USHunter College · USNew York University · US

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
The Structural Dynamics of Translation InitiationR01GM084288 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GONZALEZ, RUBEN L · 2009 to 2022
$4.4M
The mechanism through which mRNA translation enhancer elements drive cap-independent translationR01GM128239 · NIGMS · HUNTER COLLEGE · PI GOSS, DIXIE J · 2019 to 2022
$1.3M
NCATS NIH HHS UL1 TR002384NIGMS NIH HHS R01 GM084288NIGMS NIH HHS R01 GM128239
6 · The paper itself

Abstract

During unfavorable conditions (

Indexed as

5' Untranslated RegionsEukaryotic Initiation Factor-4GHumansProtein BindingProtein BiosynthesisProtein DomainsRNA CapsRNA, Messenger5' Untranslated RegionsEIF4G1 protein, humanEIF4G2 protein, humanEukaryotic Initiation Factor-4GRNA CapsRNA, Messenger5′ cap-independent translation enhancer (CITE)cap-independent translationcell stressdeath-associated protein 5 (DAP5)eukaryotic translation initiation factor 4G (eIF4G)eukaryotic translation initiation factor 4 GI (eIF4GI)fluorescence anisotropygene expressiongene regulationhypoxia-inducible factor 1α (HIF-1α)hypoxia-inducible factor (HIF)internal ribosome entry site (IRES)mRNAprotein-nucleic acid interactionprotein synthesis

Identifiers

PMID32571876
PMCPMC7450097
OpenAlexW3036945953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.