Evidence map›Paper›PMID 32571845›Full record

ArticleDisease models & mechanisms2020

The transcription factor

Olga Medina-Martinez, Meade Haller, Jill A Rosenfeld, Marisol A O'Neill, Dolores J Lamb, Milan Jamrich

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. A Hypothesis: Metabolic Contributions to 16p11.2 Deletion Syndrome.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  5. Article
  6. Streamlined identification of clinically and functionally relevant genetic regulators of lower-tract urogenital development.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Review
  9. Male infertility.Nature reviews. Disease primers · 2023
    Review
  10. Article
  11. Downregulation ofGenes & diseases · 2022
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Olga Medina-MartinezDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA olgamm@bcm.edu.ORCID 0000-0003-3515-9786
Meade HallerDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Jill A RosenfeldMolecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Marisol A O'NeillDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Dolores J LambDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Milan JamrichDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Baylor College of Medicine · US

Funding

Targeting sperm-specific proteins during meiosis and sperm morphogenesisP01HD087157 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 2017 to 2021
$6.2M
Optimization and pre-clinical evaluation of ADCY10 inhibitorsP50HD100549 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVIN, LONNY R · 2019 to 2021
$6.0M
Improving the Diagnosis of Congenital Genitourinary Defects.R01DK078121 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI LAMB, DOLORES JEAN · 2007 to 2021
$4.8M
UROLOGIC RESEARCH CAREER DEVELOPMENT PROGRAM (T32)T32DK007763 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI LAMB, DOLORES JEAN · 1999 to 2016
$1.4M
FUNCTIONAL GENOMICS AND PROTEOMICS TO REVEAL REPRODUCTIVE-TRACT SPECIFIC PROTEINSR01HD095341 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GARCIA, THOMAS · 2018 to 2020
$1.2M
Rx Regulatory Network During Retinal Development.R21EY027427 · NEI · BAYLOR COLLEGE OF MEDICINE · PI JAMRICH, MILAN ALEXANDER · 2017 to 2018
$436k
NEI NIH HHS R21 EY027427NICHD NIH HHS P01 HD087157NICHD NIH HHS P50 HD100549NICHD NIH HHS R01 HD095341NIDDK NIH HHS R01 DK078121NIDDK NIH HHS T32 DK007763
6 · The paper itself

Abstract

Wnt/β-catenin signaling has an essential role in eye development. Faulty regulation of this pathway results in ocular malformations, owing to defects in cell-fate determination and differentiation. Herein, we show that disruption of

Indexed as

AdolescentAdultAnimalsApoptosisCell ProliferationChild, PreschoolDNA-Binding ProteinsDNA Copy Number VariationsEyeEye AbnormalitiesFemaleGene DosageGene Expression Regulation, DevelopmentalGenetic Predisposition to DiseaseHumansInfantc-MYC-associated zinc finger proteinDNA-Binding ProteinsTranscription FactorsCNV 16p11.2EyeMazSfrp2Wnt pathway

Identifiers

PMID32571845
PMCPMC7449797
OpenAlexW3035938294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.