Evidence map›Paper›PMID 32571828›Full record

ArticleAntimicrobial agents and chemotherapy2020

Rapidly Correcting Frameshift Mutations in the Mycobacterium tuberculosis

Hassan Safi, Subramanya Lingaraju, Shuyi Ma, Seema Husain, Mainul Hoque, Patricia Soteropoulos, Tige Rustad, David R Sherman, David Alland

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Clinically encountered growth phenotypes of tuberculosis-causing bacilli and theirFrontiers in cellular and infection microbiology · 2022
    Review
  7. The evolving biology ofFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hassan SafiCenter for Emerging Pathogens, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Subramanya LingarajuCenter for Emerging Pathogens, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Shuyi MaCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0003-0783-1328
Seema HusainGenomics Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Mainul HoqueGenomics Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Patricia SoteropoulosGenomics Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Tige RustadCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
David R ShermanDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.
David AllandCenter for Emerging Pathogens, Department of Medicine, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA david.alland@rutgers.edu.ORCID 0000-0001-5196-1571
Rutgers, The State University of New Jersey · USInfectious Disease Research Institute · USUniversity of Washington · US

Funding

Targeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI LEUNG, DONALD YM · 2015 to 2019
$30.6M
Systems Biology CoreU19AI162598 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SHERMAN, DAVID R · 2021 to 2025
$13.9M
Diseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3M
De facto monotherapy during multidrug TB treatment and emergence of resistanceR01AI111967 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ALLAND, DAVID, DARTOIS, VERONIQUE · 2014 to 2018
$4.2M
NIAID NIH HHS R01 AI111967NIAID NIH HHS T32 AI007509NIAID NIH HHS U19 AI117673NIAID NIH HHS U19 AI162598
6 · The paper itself

Abstract

We have identified a previously unknown mechanism of reversible high-level ethambutol (EMB) resistance in

Indexed as

Drug Resistance, BacterialEthambutolFrameshift MutationMycobacterium tuberculosisAntitubercular AgentsMicrobial Sensitivity TestsPentosyltransferasesAntitubercular AgentsEthambutolPentosyltransferasescas genesdrug resistanceembCethambutolornreversible frameshiftsmall-colony variant

Identifiers

PMID32571828
PMCPMC7449195
OpenAlexW3036513869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.