Evidence map›Paper›PMID 32571786›Full record

ArticleImmunoHorizons2020

A Bioinformatic Approach to Utilize a Patient's Antibody-Secreting Cells against

Gowrishankar Muthukrishnan, Sandeep Soin, Christopher A Beck, Alex Grier, James D Brodell, Charles C Lee, Cheryl L Ackert-Bicknell, Frances Eun-Hyung Lee, Edward M Schwarz, John L Daiss

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in ImmunoHorizons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04897971 (Use of MENSA to Improve the Diagnosis of Causative Infectious Agent and Monitor Infection Recovery in Orthopedic Spine Infection), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04897971 unknown statusnot on this mapstarted 2021, after this paper: background citation

Use of MENSA to Improve the Diagnosis of Causative Infectious Agent and Monitor Infection Recovery in Orthopedic Spine Infection

TypeobservationalSponsorUniversity of Colorado, DenverRan2021 to 2026Enrolled200ConditionsStaphylococcus Aureus Infection, Surgical Site Infection, Orthopedic Procedures, SpineArmsMedium enriched for newly synthesized antibodies in spine infection
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Osteomyelitis.Nature reviews. Disease primers · 2026
    Review
  4. Article
  5. Pathogens (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Observational
  8. Low albumin level is more strongly associated with adverse outcomes and Staphylococcus aureus infection than hemoglobin A1C or smoking tobacco.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  9. Article
  10. Serum antibodies against Staphylococcus aureus can prognose treatment success in patients with bone infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gowrishankar MuthukrishnanCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0001-7521-6154
Sandeep SoinCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0002-2211-2658
Christopher A BeckCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0003-0672-0730
Alex GrierDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642.
James D BrodellCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0001-6969-781X
Charles C LeeCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0001-9884-5893
Cheryl L Ackert-BicknellCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0003-4253-4775
Frances Eun-Hyung LeeDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA 30322.ORCID 0000-0002-6133-5942
Edward M SchwarzCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0002-4854-9698
John L DaissCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642; john_daiss@urmc.rochester.edu.ORCID 0000-0002-9690-7701
University of Rochester Medical Center · USEmory University · US

Funding

Project 2: Defining the Protective vs. Susceptible Immune Proteome of S. aureus OsteomyelitisP50AR072000 · NIAMS · UNIVERSITY OF ROCHESTER · PI Benjamin L Miller · 2017 to 2026
$13.6M
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Diagnosis of early Staphylococcus aureus infections using circulating plasmablastsR21AI119646 · NIAID · UNIVERSITY OF ROCHESTER · PI DAISS, JOHN LINFORTH · 2016 to 2017
$422k
NIAID NIH HHS R21 AI119646NIAMS NIH HHS P30 AR069655NIAMS NIH HHS P50 AR072000
6 · The paper itself

Abstract

Noninvasive diagnostics for

Indexed as

AgedAntibodies, BacterialAntibody-Producing CellsBiomarkersCase-Control StudiesComputational BiologyFemaleHumansImmunoglobulin GMaleMiddle AgedOsteomyelitisPredictive Value of TestsROC CurveStaphylococcal InfectionsStaphylococcus aureusAntibodies, BacterialBiomarkersImmunoglobulin G

Identifiers

PMID32571786
PMCPMC7737182
OpenAlexW3036353817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.