Evidence map›Paper›PMID 32571717›Full record

ReviewVaccine2020

The Brighton Collaboration standardized template for collection of key information for benefit-risk assessment of nucleic acid (RNA and DNA) vaccines.

Denny Kim, James S Robertson, Jean-Louis Excler, Richard C Condit, Patricia E Fast, Marc Gurwith, George Pavlakis, Thomas P Monath, Jonathan Smith, David Wood and 4 more

Abstract readReview
In one paragraph

Review in Vaccine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Editorial: DNA Vaccines.Frontiers in medical technology · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Denny KimJanssen Pharmaceuticals, Titusville, NJ, USA.
James S RobertsonIndependent Adviser, United Kingdom.
Jean-Louis ExclerInternational Vaccine Institute, Seoul, Republic of Korea.
Richard C ConditDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA.
Patricia E FastInternational AIDS Vaccine Initiative, New York, NY 10004, USA; Stanford School of Medicine, Palo Alto, CA 94305, USA.
Marc GurwithBrighton Collaboration, A Program of the Task Force for Global Health, Decatur, GA, USA.
George PavlakisNational Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Thomas P MonathCrozet BioPharma LLC, Devens, MA 01434, USA.
Jonathan SmithVLP Therapeutics, Gaithersburg, MD 20878, USA.
David WoodIndependent Adviser, United Kingdom.
Emily R SmithBrighton Collaboration, A Program of the Task Force for Global Health, Decatur, GA, USA.
Robert T ChenBrighton Collaboration, A Program of the Task Force for Global Health, Decatur, GA, USA.
Sonali KochharGlobal Healthcare Consulting, New Delhi, India; University of Washington, Seattle, WA 98195, USA.
Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleic acid (DNA and RNA) vaccines are among the most advanced vaccines for COVID-19 under development. The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) has prepared a standardized template to describe the key considerations for the benefit-risk assessment of nucleic acid vaccines. This will facilitate the assessment by key stakeholders of potential safety issues and understanding of overall benefit-risk. The structured assessment provided by the template can also help improve communication and public acceptance of licensed nucleic acid vaccines.

Indexed as

Coronavirus InfectionsCOVID-19 VaccinesHumansPublic OpinionRisk AssessmentVaccines, DNAViral VaccinesCOVID-19 VaccinesVaccines, DNAViral VaccinesBenefit-riskBrighton CollaborationCEPICOVID-19DNANucleic acidRNASafetyTemplateVaccine

Identifiers

PMID32571717
PMCPMC7304391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.