Evidence map›Paper›PMID 32571400›Full record

ArticleArthritis research & therapy2020

DNA vaccine encoding heat shock protein 90 protects from murine lupus.

Aijing Liu, Fu-Dong Shi, Irun R Cohen, Giuseppe Castaldo, Giuseppe Matarese, Francisco J Quintana, Antonio La Cava

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 4 countries.

Aijing LiuDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Fu-Dong ShiBarrow Neurological Institute, Phoenix, AZ, 85013, USA.
Irun R CohenDepartment of Immunology, The Weizmann Institute of Science, 7610001, Rehovot, Israel.
Giuseppe CastaldoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Federico II University of Naples, Naples, 80131, Italy.
Giuseppe MatareseDipartimento di Medicina Molecolare e Biotecnologie Mediche, Federico II University of Naples, Naples, 80131, Italy.
Francisco J QuintanaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Antonio La CavaDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. alacava@mednet.ucla.edu.ORCID 0000-0002-8839-0933
Barrow Neurological Institute · USBrigham and Women's Hospital · USHebei Medical University · CNInstitute for Experimental Endocrinology and Oncology · ITUniversity of California, Los Angeles · USUniversity of Naples Federico II · ITWeizmann Institute of Science · IL

Funding

Antibody-mediated suppression of autoimmunity in humanized miceR21HD097531 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LA CAVA, ANTONIO · 2019 to 2020
$357k
NICHD NIH HHS R21 HD097531NIH HHS HD097531
6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and abnormal immune responses to it in SLE, we investigated whether an HSP90 DNA vaccine could modulate the development and clinical manifestations of SLE in lupus-prone mice.

methods(NZB x NZW)F

resultsVaccination with HSP90 DNA reduced lupus disease manifestations and prolonged the survival of NZB/W mice. The protective effects of the HSP90 DNA vaccine associated with the induction of tolerogenic dendritic cells (DCs) and an expansion of T regulatory cells (Tregs).

conclusionsThe beneficial effects of DNA vaccination with HSP90 in murine SLE support the possibility of HSP90-based therapeutic modalities of intervention in SLE.

Indexed as

Lupus Erythematosus, SystemicVaccines, DNAAnimalsAutoantibodiesDisease Models, AnimalHeat-Shock ProteinsMiceMice, Inbred NZBAutoantibodiesHeat-Shock ProteinsVaccines, DNAAutoimmunityDNA vaccineHeat shock proteinsSystemic lupus erythematosusT regulatory cells

Identifiers

PMID32571400
PMCPMC7310240
OpenAlexW3035880009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.