Evidence map›Paper›PMID 32571391›Full record

Observational studyBMC research notes2020

Electro-oculography in bilateral optic neuropathy.

Padmini Dahanayake, Tharaka L Dassanayake, Manoji Pathirage, Saman Senanayake, Mike Sedgwick, Vajira Weerasinghe

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Padmini DahanayakeDepartment of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka. padminid@pdn.ac.lk.
Tharaka L DassanayakeDepartment of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka.
Manoji PathirageTeaching Hospital, Peradeniya, 20400, Sri Lanka.
Saman SenanayakeEye Unit, National Hospital, Kandy, 20000, Sri Lanka.
Mike SedgwickDepartment of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka.
Vajira WeerasingheDepartment of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka.
University of Peradeniya · LKUniversity of Newcastle Australia · AU

Funding

University of Peradeniya URG/2016/44/M
6 · The paper itself

Abstract

objectiveEffect of bilateral, optic neuropathy on the function of retinal pigment epithelium has not been investigated extensively to date. This study aimed to determine the effect of bilateral, optic neuropathy on light peak:dark trough ratio, light peak and dark trough values of electro-oculography. Thirty-seven patients with a clinical diagnosis of bilateral optic neuropathy and 40 control subjects were recruited in this observational, cross-sectional study, carried out at the Neurophysiology unit, Teaching Hospital, Peradeniya, Sri Lanka. Pattern reversal visual evoked potentials, pattern electroretinography and electro-oculography were recorded in all of them.

resultsTwenty-four patients (64.9%) had reduced light peak:dark trough ratio values. The median light peak:dark trough ratio ± inter quartile range of the patient group (1.50 ± 0.4) was significantly lower than that of the controls (1.80 ± 0.2), (p < 0.001). Median dark trough value was significantly higher in patients compared to the control value. These changes may be due to higher conductance of ion channels in the retinal pigment epithelium, sub retinal space creation, changes in choroidal circulation or secondary to photoreceptor abnormalities in the macular region. These results indicate that retinal pigment epithelium might be affected in bilateral optic neuropathy.

Indexed as

ElectrooculographyAdultCross-Sectional StudiesElectroretinographyEvoked Potentials, VisualFemaleHumansMaleMiddle AgedOptic Nerve DiseasesYoung AdultBilateralElectro-oculographyLP:DT ratioOptic neuropathy

Identifiers

PMID32571391
PMCPMC7310542
OpenAlexW3035834718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.