Evidence map›Paper›PMID 32571342›Full record

ArticleHealth and quality of life outcomes2020

Validation of a vision-related activity scale for patients with retinitis pigmentosa.

Francisco M Costela, Konrad Pesudovs, Michael A Sandberg, Carol Weigel-DiFranco, Russell L Woods

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Health and quality of life outcomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Choroideremia: The Endpoint Endgame.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Francisco M CostelaSchepens Eye Research Institute, 20 Staniford St, Boston, MA, 02114, USA. Francisco_costela@meei.harvard.edu.ORCID http://orcid.org/0000-0002-3530-6224
Konrad PesudovsSchool of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
Michael A SandbergDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Carol Weigel-DiFrancoMassachusetts Eye and Ear, Boston, MA, USA.
Russell L WoodsSchepens Eye Research Institute, 20 Staniford St, Boston, MA, 02114, USA.
Harvard University · USMassachusetts Eye and Ear Infirmary · USUNSW Sydney · AU

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
Impact of Peripheral Islands in the Visual Field on Functional Ability in Patients with Retinitis PigmentosaR21EY027882 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WOODS, RUSSELL LAURENCE · 2017 to 2018
$561k
NEI NIH HHS EY027882NEI NIH HHS P30 EY003790NEI NIH HHS R21 EY027882
6 · The paper itself

Abstract

purposeThere have been few systematic reports of vision-related activity limitations of people with retinitis pigmentosa (RP). We report a merging of data from the National Eye Institute Visual Function Questionnaire (NEI-VFQ) obtained in five previous studies. We asked whether the Vision Function Scale (VFS; Pesudovs et al., 2010) which was developed for cataract patients would apply in this new population (condition).

methodsFive hundred ninety-four individuals completed a total of 1753 questionnaires, with 209 participants providing responses over at least 4 years. Rasch analysis showed that the 15-item VFS was poorly targeted. A new instrument created by adding four driving-related items to the VFS had better targeting. As an indirect validation, VFS-plus person scores were compared to visual field area measured using a Goldmann perimeter, to the summed score for the combined 30-2 and 30/60-1 Humphrey Field Analyzer programs (HFA), to 30-Hz full-field cone electroretinogram (ERG) amplitude, and to ETDRS visual acuity. Changes in VFS-plus person scores with age and between four common heredity groups were also examined.

resultsThe Rasch model of responses to the 19 VFS-plus items had person and item separation of 2.66 and 24.43 respectively. The VFS-plus person scores were related to each vision measure (p < 0.001). Over a five-year period, there was a reduction in person scores of 0.5 logits (p < 0.001). Person scores fell by an average of 0.34 logits per decade (p < 0.0001). Participants with an X-linked hereditary pattern had, on average, lower person scores (p < 0.001).

conclusionsThe VFS-plus instrument quantified a highly-significant annual reduction in perceived vision-related ability over a five-year period. The outcome was consistent with clinical measures of vision, and detected lower perceived vision-related ability in participants with X-linked disease. It may be of use in future studies, but this needs to be tested in a representative population sample.

Indexed as

Activities of Daily LivingAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNational Eye Institute (U.S.)Reproducibility of ResultsRetinitis PigmentosaSurveys and QuestionnairesSymptom AssessmentUnited StatesVision, LowVisual AcuityQuality of lifeRaschRetinitis pigmentosa

Identifiers

PMID32571342
PMCPMC7310073
OpenAlexW3036970385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.