Evidence map›Paper›PMID 32570974›Full record

ArticleCancers2020

Comparison of Hodgkin's Lymphoma in Children and Adolescents. A Twenty Year Experience with MH'96 and LH2004 AIEOP (Italian Association of Pediatric Hematology and Oncology) Protocols.

Roberta Burnelli, Giulia Fiumana, Roberto Rondelli, Marta Pillon, Alessandra Sala, Alberto Garaventa, Emanuele S G D'Amore, Elena Sabattini, Salvatore Buffardi, Maurizio Bianchi and 25 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Roberta BurnelliPediatric Hemato-Oncology Unit, Azienda Ospedaliero Universitaria Sant'Anna di Ferrara, 44124 Cona, Ferrara, Italy.ORCID 0000-0002-8437-1954
Giulia FiumanaDepartment of Pediatrics, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico, 41121 Modena, Italy.
Roberto RondelliDepartment of Pediatrics, Sant'Orsola Hospital, University of Bologna, 40138 Bologna, Italy.
Marta PillonPediatric Hematology, Oncology and Stem Cell Transplant Center, Department of Women and Child's Health, University of Padua, 35122 Padova PD, Italy.
Alessandra SalaDepartment of Paediatrics, Ospedale San Gerardo, University of Milano-Bicocca, Fondazione MBBM, 20900 Monza, Italy.ORCID 0000-0002-6807-9806
Alberto GaraventaDepartment of Pediatric Oncology, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Emanuele S G D'AmoreDepartment of Pathological Anatomy, San Bortolo Hospital, 36100 Vicenza, Italy.
Elena SabattiniDepartment of Experimental, Diagnostic and Speciality Medicine, University of Bologna, 40126 Bologna, Italy.
Salvatore BuffardiPaediatric Haemato-Oncology Department, Santobono-Pausilipon Children's Hospital, 80122 Napoli, Italy.
Maurizio BianchiPediatric Onco-Hematology and Stem Cell Transplant Division, City of Health and Science, Regina Margherita Children's Hospital, 10126 Turin, Italy.
Luciana VintiDepartment of Pediatric Hematology and Oncology, IRCSS Ospedale Bambino Gesù, 00165 Rome, Italy.
Marco ZeccaOncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0002-8818-1744
Paola MuggeoDepartment of Pediatric Oncology and Hematology, University Hospital of Policlinico, 70124 Bari, Italy.
Massimo ProvenziDepartment of Pediatrics, Civic Hospital, 24127 Bergamo, Italy.
Piero FarruggiaPediatric Hematology and Oncology Unit, Oncology Department, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, 90127 Palermo, Italy.
Francesca RossiDepartment of Woman, Child and of General and Specialist Surgery, Second University of Naples, 81100 Naples, Italy.
Salvatore D'AmicoDepartment of Clinical and Experimental Medicine, Paediatric Haemato-Oncology Unit, University of Catania, 95124 Catania, Italy.
Elena FacchiniDepartment of Pediatrics, Sant'Orsola Hospital, University of Bologna, 40138 Bologna, Italy.
Sayla BernasconiPediatric Hematology Oncology, Bone Marrow Transplant, S. Chiara University Hospital of Pisa, 56126 Pisa, Italy.
Raffaela De SantisIRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 47156 Foggia, Italy.
Tommaso CasiniPaediatric Haematology-Oncology Unit, Meyer Paediatric Hospital, 50139 Florence, Italy.
Fulvio PortaOncology-Hematology and BMT Unit, Ospedale dei Bambini, Spedali Civili, 25123 Brescia, Italy.
Irene D'AlbaDivision of Pediatric Hematology and Oncology, Ospedale G. Salesi, 60123 Ancona, Italy.
Rosamaria MuraPediatric Hematology and Oncology Unit, Ospedale Pediatrico Microcitemico, 09121 Cagliari, Italy.
Federico VerzegnassiPaediatric Onco-Haematology Unit, "Burlo Garofolo" Hospital, 34137 Trieste, Italy.
Antonella SauPediatric Hematology-Oncology Unit, Ospedale Civico, Pescara, Italy.
Simone CesaroPediatric Hematology Oncology Unit, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, 37126 Verona, Italy.ORCID 0000-0002-8698-9547
Katia PerruccioPediatric Hematology-Oncology Unit, S. Maria della Misericordia Hospital, 65124 Perugia, Italy.
Monica CelliniDepartment of Pediatrics, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico, 41121 Modena, Italy.
Patrizia BertoliniPediatric Hematology Oncology Unit, Azienda Ospedaliero Universitaria of Parma, 43126 Parma, Italy.
Domenico SperlìPediatric Unit, Azienda Ospedaliera Annunziata, 87100 Cosenza, Italy.
Roberta PericoliPediatric Oncology Unit, Infermi Hospital, 47923 Rimini, Italy.
Daniela GalimbertiAzienda Ospedaliero Universitaria Senese Policlinico "Le Scotte", Clinica Pediatrica, 53100 Siena, Italy.
Adele CivinoPediatric Rheumatology and Immunology, PO "Vito Fazzi", 73100 Lecce, Italy.
Maurizio MascarinAYA Oncology and Pediatric Radiotherapy Unit, CRO-Centro di Riferimento Oncologico di Aviano, IRCCS, 33081 Aviano, Italy.ORCID 0000-0002-2828-0257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adolescents and young adults (AYAs) represent a distinct group of patients. The objectives of this study were: To compare adolescent prognosis to that of younger children; to compare the results achieved with the two consecutive protocols in both age groups; to analyze clinical characteristics of children and adolescents. Between 1996 and 2017, 1759 patients aged <18 years were evaluable for the study. Five hundred and sixty patients were treated with the MH'96 protocol and 1199 with the LH2004 protocol. Four hundred and eighty-two were adolescents aged ≥15 years. Patients in both age groups showed very favorable prognoses. In particular, OS improved with the LH2004 protocol, especially in the adolescent group and in the low risk group, where radiation therapy was spared. Adolescent characteristics differed significantly from the children's according to sex, histology, and the presence of symptoms. Remarkable is the decrease both in mixed cellularity in the children and in low stages in both age groups in the LH2004 protocol with respect to MH'96 protocol. Based on our experience, adopting pediatric protocols for AYA does not compromise patient outcomes.

Indexed as

adolescentchemotherapychildrenclinical characteristicshistologyHodgkin’s lymphomapediatricprognosisradiotherapy

Identifiers

PMID32570974
PMCPMC7352443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.