ReviewNutrients2020
Uremic Sarcopenia: Clinical Evidence and Basic Experimental Approach.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 61 citations in OpenAlex.
- Associations between frailty, physical performance, and renal biomarkers in older people with advanced chronic kidney disease.European geriatric medicine · 2021Trial
- Article
- Rehabilitation Exercise Behaviors in Patients Undergoing Peritoneal Dialysis: A Mixed-Methods Study on Multidimensional Determinants.Archives of rehabilitation research and clinical translation · 2026Article
- Pathological changes and therapeutic strategies for sarcopenia.EFORT open reviews · 2026Review
- Revisiting the Sarcopenic Index in Older Adults with Reduced Kidney Function: Association with EWGSOP2-Defined Probable Sarcopenia.Journal of clinical medicine · 2026Article
- Association between malnutrition risk and diabetic nephropathy in adult patients with type 2 diabetes: a cross-sectional study and mediation analysis.BMC endocrine disorders · 2026Article
- Digital health technologies for the management of sarcopenia in patients receiving maintenance hemodialysis: a narrative review.Frontiers in nutrition · 2026Review
- Biomarkers Linked to Malnutrition Identified According to GLIM Criteria Among Older Community-Dwelling Adults: Results from the ilSIRENTE Study.Nutrients · 2025Article
- Pharmacological prolyl hydroxylase inhibition enhances high-intensity exercise capacity in mice.Physiological reports · 2025Article
- Risks of All-Cause Mortality in Adults With Chronic Kidney Disease With Sarcopenia or Obesity: A Population-Based Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- From fat to filter: the effect of adipose tissue-derived signals on kidney function.Nature reviews. Nephrology · 2025Review
- Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model.International journal of molecular sciences · 2025Article
- Review
- Knowledge, attitudes, and practice toward sarcopenia among maintenance dialysis patients in Anhui, China.BMC public health · 2025Article
- Nonleisure-time physical activity as a protective factor against sarcopenia in hemodialysis patients: a prospective cohort study.Frontiers in nutrition · 2025Article
- Effects of mindfulness meditation combined with progressive muscle relaxation on sleep disorders, anxiety, and depression in patients with sarcopenia undergoing hemodialysis.Frontiers in psychiatry · 2025Article
- Bioelectrical impedance analysis-derived phase angle predicts possible Sarcopenia in patients on maintenance hemodialysis: a retrospective study.BMC nephrology · 2024Article
- Association of endothelial dysfunction and peripheral arterial disease with sarcopenia in chronic kidney disease.Journal of cachexia, sarcopenia and muscle · 2024Article
- Skeletal Muscle Injury in Chronic Kidney Disease-From Histologic Changes to Molecular Mechanisms and to Novel Therapies.International journal of molecular sciences · 2024Review
- The role of ultra-processed food consumption in protein-energy wasting and sarcopenia development in patients with chronic kidney diseases.BMC nephrology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sustained physical activity extends healthy life years while a lower activity due to sarcopenia can reduce them. Sarcopenia is defined as a decrease in skeletal muscle mass and strength due not only to aging, but also from a variety of debilitating chronic illnesses such as cancer and heart failure. Patients with chronic kidney disease (CKD), who tend to be cachexic and in frail health, may develop uremic sarcopenia or uremic myopathy due to an imbalance between muscle protein synthesis and catabolism. Here, we review clinical evidence indicating reduced physical activity as renal function deteriorates and explore evidence-supported therapeutic options focusing on nutrition and physical training. In addition, although sarcopenia is a clinical concept and difficult to recapitulate in basic research, several in vivo approaches have been attempted, such as rodent subtotal nephrectomy representing both renal dysfunction and muscle weakness. This review highlights molecular mechanisms and promising interventions for uremic sarcopenia that were revealed through basic research. Extensive study is still needed to cast light on the many aspects of locomotive organ impairments in CKD and explore the ways that diet and exercise therapies can improve both outcomes and quality of life at every level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.