Evidence map›Paper›PMID 32570581›Full record

ArticleStudies in health technology and informatics2020

Association of C>U RNA Editing with Human Disease Variants.

Sapan Mandloi, Zackary Falls, Rong Deng, Ram Samudrala, Peter L Elkin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Studies in health technology and informatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sapan MandloiDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
Zackary FallsDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
Rong DengJacobs School Of Medicine And Biomedical Sciences, Buffalo, NY, USA.
Ram SamudralaDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
Peter L ElkinDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
University at Buffalo, State University of New York · USJacobs Institute · USVA Western New York Healthcare System · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
National Library of Medicine Conference 2022T15LM012495 · NLM · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PETER L. ELKIN · 2017 to 2026
$4.3M
NOVEL PARADIGMS FOR DRUG DISCOVERY: COMPUTATIONAL MULTITARGET SCREENINGDP1LM011509 · NLM · UNIVERSITY OF WASHINGTON · PI SAMUDRALA, RAM · 2012 to 2014
$2.4M
NOVEL PARADIGMS FOR DRUG DISCOVERY: COMPUTATIONAL MULTITARGET SCREENINGDP1OD006779 · OD · UNIVERSITY OF WASHINGTON · PI SAMUDRALA, RAM · 2010 to 2011
$1.7M
Reconstruction and Modeling of Dynamical Molecular NetworksR01LM012595 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$1.3M
Pain Medication Prescriptions and Misuse Following Treatment for Alcohol Use DisordersR21AA026954 · NIAAA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ELKIN, PETER L., LEONARD, KENNETH E · 2018 to 2019
$386k
NCATS NIH HHS UL1 TR001412NIAAA NIH HHS R21 AA026954NIH HHS DP1 OD006779NLM NIH HHS DP1 LM011509NLM NIH HHS R01 LM012595NLM NIH HHS T15 LM012495
6 · The paper itself

Abstract

RNA-editing is an important post-transcriptional RNA sequence modification performed by two catalytic enzymes, "ADAR"(A>I) and "APOBEC"(C>U). Although APOBEC-mediated C>U editing has been associated with a number of human cancers, the extent of C>U editing in human disease remains unclear. Here, we performed an association study and found that at least 1293 human disease variants occur at sites predicted by sequence motif analysis (RNASee protocol) to undergo APOBEC3A/G C>U editing. These variants were associated with a wide array of human disease conditions ranging from cancer, metabolic disorders, retinopathies, cardiomyopathies, neurodegenerative disorders and immunodeficiencies. These results indicate that APOBEC mediated C>U RNA editing may have widespread and previously unreported contributions to human disease conditions.

Indexed as

RNA EditingAPOBEC-1 DeaminaseCytidine DeaminaseHumansProteinsAPOBEC-1 DeaminaseAPOBEC3A protein, humanCytidine DeaminaseProteinsCytidine deaminaseProtein diversityRNA-editing

Identifiers

PMID32570581
PMCPMC10354784
OpenAlexW3036718080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.