Evidence map›Paper›PMID 32570271›Full record

Observational studyPediatric research2021

Progression of left ventricular diastolic function in the neonate and early childhood from transmitral color M-mode filling analysis.

Collin T Erickson, Brett Meyers, Ling Li, Mary Craft, Vivek Jani, John Bliamptis, Karl Stessy Bisselou Moukagna, David A Danford, Pavlos Vlachos, Shelby Kutty

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Collin T EricksonDepartment of Pediatric Cardiology, University of Nebraska College of Medicine and Children's Hospital and Medical Center, Omaha, NE, USA.
Brett MeyersDepartment of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Ling LiDepartment of Pediatric Cardiology, University of Nebraska College of Medicine and Children's Hospital and Medical Center, Omaha, NE, USA.
Mary CraftDepartment of Pediatric Cardiology, University of Nebraska College of Medicine and Children's Hospital and Medical Center, Omaha, NE, USA.
Vivek JaniTaussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD, USA.
John BliamptisTaussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD, USA.
Karl Stessy Bisselou MoukagnaDepartment of Pediatric Cardiology, University of Nebraska College of Medicine and Children's Hospital and Medical Center, Omaha, NE, USA.
David A DanfordDepartment of Pediatric Cardiology, University of Nebraska College of Medicine and Children's Hospital and Medical Center, Omaha, NE, USA.
Pavlos VlachosDepartment of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Shelby KuttyTaussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD, USA. skutty1@jhmi.edu.
Children's Hospital & Medical Center · USJohns Hopkins Hospital · USPurdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe implemented sophisticated color M-mode analysis to assess age-dependent progression of left ventricular (LV) diastolic function.

methodsNormal infants were prospectively enrolled for serial echocardiograms at 1 week, 1 month, 6 months, 1 year, and 2 years. From color M-mode scans, propagation velocity (V

resultsAge-wise comparisons of diastolic filling from 121 echocardiograms in 31 infants showed V

conclusionsComprehensive analysis of transmitral color M-mode data is feasible in infants, enabling calculation of pressure drop between the LV base and apex and strength of propagation from two distinct slopes. Profound changes very early followed by relatively constant filling mechanics in later infancy indicate significant LV maturation occurring during the first month of life. IMPACT: We implemented sophisticated analytic methods for color M-mode echocardiography in infants to assess age- and dimension-dependent changes in left ventricular diastolic function. Comprehensive characterization of transmitral color M-mode flow was feasible, enabling calculation of pressure drop between left ventricular base and apex and strength of propagation. Left ventricular diastolic filling function has predictable maturational progression, with significant differences in the intraventricular pressure between infants from birth to 2 years. This study forms the basis for future studies to examine alteration of early diastolic filling in congenital heart disease.

Indexed as

Blood Flow VelocityChild, PreschoolDiastoleDisease ProgressionEchocardiographyEchocardiography, Doppler, ColorHeartHeart VentriclesHumansInfantInfant, NewbornProspective StudiesReproducibility of ResultsStroke VolumeTime FactorsVentricular Function, Left

Identifiers

PMID32570271
OpenAlexW3036060537

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.