Evidence map›Paper›PMID 32570206›Full record

ArticleNeuroImage. Clinical2020

Characterizing the heterogeneous metabolic progression in idiopathic REM sleep behavior disorder.

Xianhua Han, Ping Wu, Ian Alberts, Hucheng Zhou, Huan Yu, Panagiotis Bargiotas, Igor Yakushev, Jian Wang, Guenter Höglinger, Stefan Förster and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  3. Neurology · 2024
    Article
  4. Stereotyped Relationship Between Motor and Cognitive Metabolic Networks in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  5. Article
  6. Longitudinal Changes in Isolated Rapid Eye Movement Sleep Behavior Disorder-Related Metabolic Pattern Expression.Movement disorders : official journal of the Movement Disorder Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 5 countries.

Xianhua HanPET Center, Huashan Hospital, Fudan University, Shanghai, China.
Ping WuPET Center, Huashan Hospital, Fudan University, Shanghai, China.
Ian AlbertsDepartment of Nuclear Medicine, University of Bern, Switzerland.
Hucheng ZhouKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication ,Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China.
Huan YuDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Panagiotis BargiotasDepartment of Neurology, University Hospital Bern (Inselspital) and University of Bern, Bern, Switzerland; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Igor YakushevDepartment of Nuclear Medicine, Technische Universität München, Munich, Germany.
Jian WangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Guenter HöglingerDepartment of Neurology, Hannover Medical School, Germany.
Stefan FörsterDepartment of Nuclear Medicine, Technische Universität München, Munich, Germany; Department of Nuclear Medicine, Klinikum Bayreuth, Germany.
Claudio BassettiDepartment of Neurology, University Hospital Bern (Inselspital) and University of Bern, Bern, Switzerland.
Wolfgang OertelDepartment of Neurology, University of Marburg, Germany.
Markus SchwaigerKlinikum r. d. Isar, Technische Universität München, Munich, Germany.
Sung-Cheng HuangDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, USA.
Paul CummingDepartment of Nuclear Medicine, University of Bern, Switzerland; School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Australia.
Axel RomingerDepartment of Nuclear Medicine, University of Bern, Switzerland.
Jiehui JiangKey Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication ,Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China. Electronic address: jiangjiehui@shu.edu.cn.
Chuantao ZuoPET Center, Huashan Hospital, Fudan University, Shanghai, China; Human Phenome Institute, Fudan University, Shanghai, China; Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China. Electronic address: zuochuantao@fudan.edu.cn.
Kuangyu ShiDepartment of Nuclear Medicine, University of Bern, Switzerland; Dept. Informatics, Technische Universität München, Munich, Germany.
Fudan University · CNUniversity of Bern · CHTechnical University of Munich · DEShanghai University · CNBayreuth Medical Center · DEHuashan Hospital · CNMedizinische Hochschule Hannover · DEPhilipps University of Marburg · DEUniversity of Cyprus · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIdiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of synucleinopathies such as Parkinson's disease (PD). Positron emission tomography (PET) with

methods19 iRBD patients, 38 PD patients and 19 HC subjects underwent

resultsPD patients exhibited more extensive relative hyper- and hypo-metabolism than iRBD patients. We identified three dynamic metabolic trajectories, cross-sectional hypo- or hypermetabolism, cross-sectionally unchanged hypo- or hypermetabolism, cross-sectionally late hypo- or hypermetabolism, appearing only in the contrast of PD with iRBD. No correlation was found between relative

conclusionCerebral metabolism changes heterogeneously in a continuum extending from HC to iRBD and PD groups in this preliminary study. The distinctive metabolic trajectories point towards a potential neuroimaging biomarker for conversion of iRBD to frank PD, which should be amenable to advanced pattern recognition analysis in future longitudinal studies.

Indexed as

Image Processing, Computer-AssistedAgedBrainCross-Sectional StudiesDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuroimagingParkinson DiseasePositron-Emission TomographyProdromal SymptomsSleep Wake DisordersConversionFDGParkinson’s diseasePETREM sleep behavior disorder

Identifiers

PMID32570206
PMCPMC7322340
OpenAlexW3032544204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.