Evidence map›Paper›PMID 32569947›Full record

ReviewCurrent opinion in cell biology2020

Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis.

Abigail Kindberg, Jimmy K Hu, Jeffrey O Bush

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Abigail KindbergProgram in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
Jimmy K HuSchool of Dentistry, University of California Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: jkhu@g.ucla.edu.
Jeffrey O BushProgram in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA. Electronic address: Jeffrey.bush@ucsf.edu.

Funding

Mechanisms of Eph/Ephrin signaling in craniofacial morphogenesis and craniofrontonasal syndromeR01DE023337 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUSH, JEFFREY OHMANN · 2013 to 2021
$4.3M
Cellular mechanisms of lip and palate fusionR01DE025877 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUSH, JEFFREY OHMANN · 2016 to 2020
$2.0M
Mechanisms of early tracheal specification and morphogenesisR01HL144785 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BUSH, JEFFREY OHMANN · 2019 to 2022
$1.6M
An investigation of the roles of mechanical signaling in YAP-mediated tooth renewR00DE025874 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HU, JIMMY KUANG-HSIEN · 2019 to 2021
$747k
Tissue tension in palate morphogenesisF31DE028175 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KINDBERG, ABIGAIL ALEXANDRA · 2018 to 2019
$76k
NHLBI NIH HHS R01 HL144785NIDCR NIH HHS F31 DE028175NIDCR NIH HHS R00 DE025874NIDCR NIH HHS R01 DE023337NIDCR NIH HHS R01 DE025877
6 · The paper itself

Abstract

Morphogenesis is a physical process that requires the generation of mechanical forces to achieve dynamic changes in cell position, tissue shape, and size as well as biochemical signals to coordinate these events. Mechanical forces are also used by the embryo to transmit detailed information across space and detected by target cells, leading to downstream changes in cellular properties and behaviors. Indeed, forces provide signaling information of complementary quality that can both synergize and diversify the functional outputs of biochemical signaling. Here, we discuss recent findings that reveal how mechanical signaling and biochemical signaling are integrated during morphogenesis and the possible context-specific advantages conferred by the interactions between these signaling mechanisms.

Indexed as

Mechanotransduction, CellularMorphogenesisSignal TransductionAnimalsBiomechanical PhenomenaCell CountHumansModels, BiologicalActomyosinDevelopmentEphEphrinForceMorphogenesisPIEZOSignalingTazTensionYap

Identifiers

PMID32569947
PMCPMC7577940

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.