ArticleAmerican journal of ophthalmology2020
Ocular Manifestations and Burden Related to Sjögren Syndrome: Results of a Patient Survey.
Article in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Characteristics of Tear Film in Sjögren's Syndrome Patients as Measured by a Novel Tear Film Imager: A Pilot Study.Journal of clinical medicine · 2026Article
- When Dryness Extends to the Brain: Brain-Related Non-Sicca Manifestations of Sjögren's Disease.Journal of clinical medicine · 2026Review
- Patient-Reported Symptoms Versus Clinician-Measured Signs to Distinguish Sjogren's in Patients With Dry Eye.Translational vision science & technology · 2026Article
- Comparison of SPEED and OSDI questionnaires for dry eye symptom in Chinese college students: a cross-sectional study.BMC ophthalmology · 2025Article
- The Proportion of Ocular Involvement and Characteristics of Dry Eye Parameters in Primary Sjögren Syndrome Referred from the Rheumatology Department.Korean journal of ophthalmology : KJO · 2024Article
- Brazilian version of the "Primary Sjögren's Syndrome - Quality of Life questionnaire (PSS-QoL)": translation, cross-cultural adaptation and validation.Advances in rheumatology (London, England) · 2024Article
- Laboratory features and pharmacological management of early and late-onset primary Sjögren's syndrome.Rheumatology international · 2024Article
- Patient Experience of Sjögren's Disease and its Multifaceted Impact on Patients' Lives.Rheumatology and therapy · 2023Article
- A comprehensive overview of living with Sjögren's: results of a National Sjögren's Foundation survey.Clinical rheumatology · 2022Review
- Sjögren's Syndrome Associated Dry Eye: Impact on Daily Living and Adherence to Therapy.Journal of clinical medicine · 2022Article
- Impact of the COVID-19 pandemic on eye strain and dry eye symptoms.The ocular surface · 2021Article
- National Sjögren's Foundation Survey: Burden of Oral and Systemic Involvement on Quality of Life.The Journal of rheumatology · 2021Article
- Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample.PloS one · 2021Observational
- Epidemiology of Ocular Manifestations in Autoimmune Disease.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
purposeTo compare the burden related to dry eye with systemic symptoms of Sjögren syndrome; to estimate the burden related to ocular treatments; and to compare the impact of dry eye and extraocular manifestations of Sjögren syndrome on various aspects of patient life.
designCross-sectional study.
methodsWe conducted a postal survey of adult patients with a history of physician-diagnosed Sjögren syndrome.
resultsThe survey was completed by 2,961 patients (mean age 65.1 years, standard deviation 11.7 years), most of whom were women (96%) and white (94%). Forty-one patients younger than 18 years of age were excluded. More than half (53%) experienced severe dry eye (ie, dry eye daily/almost daily with major impact on their life). Corresponding proportions for dry mouth and fatigue were 48% and 45%, respectively. Almost all patients (97%) had used nonprescription eye drops/artificial tears/ointments. Compared with patients who did not experience dry eye, those who experienced significant dry eye (ie, daily/almost daily dry eye) more often agreed that living with Sjögren syndrome made every day a challenge (adjusted odds ratio [OR] 3.81, 95% confidence interval [CI] 2.49 to 5.86) and added a significant emotional burden (adjusted OR 2.22, 95% CI 1.49 to 3.31). Adjusted ORs for the impact of dry eye were generally lower than those for fatigue, but were similar to dry mouth and considerably higher than use of systemic treatments for serious manifestations of the disease and diagnosis of lymphoma.
conclusionsSjögren-related dry eye is more burdensome than systemic manifestations of the disease. While fatigue has the greatest impact on patient life, the impact of dry eye is comparable to that of other systemic manifestations.
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