ArticleAmerican journal of respiratory and critical care medicine2020
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
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Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Rhinovirus infection promotes suppression of sphingosine and enhanced bacterial infection in cystic fibrosis airways.The Journal of biological chemistry · 2026Article
- Elevated Serum Levels of Acid Sphingomyelinase in Female Patients with Episodic and Chronic Migraine.Antioxidants (Basel, Switzerland) · 2025Article
- Sphingolipid Metabolism Is Associated with Cardiac Dyssynchrony in Patients with Acute Myocardial Infarction.Biomedicines · 2024Article
- Sphingolipid-Induced Bone Regulation and Its Emerging Role in Dysfunction Due to Disease and Infection.International journal of molecular sciences · 2024Review
- Sphingosine kills intracellular Pseudomonas aeruginosa and Staphylococcus aureus.Pathogens and disease · 2024Article
- Unleashing AdipoRon's Potential: A Fresh Approach to TackleJournal of inflammation research · 2024Article
- New Therapeutic Options in Pulmonal Diseases: Sphingolipids and Modulation of Sphingolipid Metabolism.Handbook of experimental pharmacology · 2024Review
- Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery.Handbook of experimental pharmacology · 2024Article
- Reduced Sphingosine in Cystic Fibrosis Increases Susceptibility toInternational journal of molecular sciences · 2023Article
- Cross-talk between CFTR and sphingolipids in cystic fibrosis.FEBS open bio · 2023Review
- Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction.Respiratory research · 2023Article
- Acid Ceramidase Deficiency: Bridging Gaps between Clinical Presentation, Mouse Models, and Future Therapeutic Interventions.Biomolecules · 2023Review
- Lipidomic alterations in human saliva from cystic fibrosis patients.Scientific reports · 2023Article
- Post-approval studies with the CFTR modulators Elexacaftor-Tezacaftor-Ivacaftor.Frontiers in pharmacology · 2023Review
- Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor toInfection and drug resistance · 2023Article
- Lipidomics Profiles and Lipid Metabolite Biomarkers in Serum of Coal Workers' Pneumoconiosis.Toxics · 2022Article
- Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs.PloS one · 2022Article
- Mechanistic analysis and significance of sphingomyelinase-mediated decreases in transepithelial CFTR currents in nHBEs.Physiological reports · 2021Article
- Update in Pediatrics 2020.American journal of respiratory and critical care medicine · 2021Article
- Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR-mediated apical conductance.Physiological reports · 2021Article
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 4 countries.
Aaron I GardnerTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.ORCID 0000-0001-8729-9823
Iram J HaqTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.ORCID 0000-0002-5795-0440
A John SimpsonTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.ORCID 0000-0003-4731-7294
Katrin A BeckerDepartment of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
John GallagherTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.
Vinciane Saint-CriqBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Bernard VerdonBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Emily MavinTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.
Alexandra TriggTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.
Michael A GrayBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Albert KoulmanNational Institute for Health Research Biomedical Research Centre Metabolomics and Lipidomics Facility, University of Cambridge, Cambridge, United Kingdom.
Melissa J McDonnellBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Andrew J FisherTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.
Elizabeth L KramerDepartment of Pediatrics and.
John P ClancyDepartment of Pediatrics and.
Christopher WardTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.ORCID 0000-0002-6954-9611
Edward H SchuchmanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; and.
Erich GulbinsDepartment of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
Malcolm BrodlieTranslational and Clinical Research Institute, Faculty of Medical Sciences, and.ORCID 0000-0003-4591-8299
Clinical Research Institute · USNewcastle University · GBCincinnati Children's Hospital Medical Center · USUniversity of Duisburg-Essen · DEIcahn School of Medicine at Mount Sinai · USNational Health Service · GBUniversity Hospital Galway · IEUniversity of Cambridge · GB
Funding
Medical Research Council MC_UU_00014/5Medical Research Council MR/M008797/1Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
Acid CeramidaseAdolescentAlveolar Epithelial CellsAnimalsBlotting, WesternCells, CulturedChildCystic FibrosisHumansInflammationMass SpectrometryMicePneumoniaPolymerase Chain ReactionPseudomonas InfectionsSensitivity and SpecificityAcid CeramidaseSphingolipidsceramidelungsphingolipidsphingosine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.