ReviewOral diseases2021
Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer.
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In one paragraph
Review in Oral diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment.The Cochrane database of systematic reviews · 2023Pooled it
- Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.The Cochrane database of systematic reviews · 2021Pooled it
- Associations of combined lifestyle and genetic risk with incident head and neck cancer: a prospective study in the UK Biobank.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Article
- Oral health-related quality of life in head and neck cancer survivors in Egypt within the first year after radiotherapy: a multivariable analysis.BMC oral health · 2025Article
- An epidemiological trend analysis of oral cancer in Korea from 2001 to 2021.BMC oral health · 2025Article
- Advancing Head and Neck Cancer Therapies: From Conventional Treatments to Emerging Strategies.Biomedicines · 2025Review
- Article
- Causal associations between dietary factors with head and neck cancer: A two-sample Mendelian randomization study.Laryngoscope investigative otolaryngology · 2025Article
- Article
- Analysis of mutational variations inEcancermedicalscience · 2024Article
- From standard therapies to monoclonal antibodies and immune checkpoint inhibitors - an update for reconstructive surgeons on common oncological cases.Frontiers in immunology · 2024Review
- Serum and Saliva Level of miR-31-5p and miR-let 7a in EBV Associated Oropharyngeal Cancer.International journal of molecular sciences · 2023Article
- Review
- Dietary intervention for tertiary prevention in head and neck squamous cell carcinoma survivors: clinical and translational results of a randomized phase II trial.Frontiers in oncology · 2023Article
- Disparities in head and neck cancer incidence and trends by race/ethnicity and sex.Head & neck · 2023Article
- Is ChatGPT accurate and reliable in answering questions regarding head and neck cancer?Frontiers in oncology · 2023Article
- A Biflavonoid-Rich Extract fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Risk prediction models for head and neck cancer: A rapid review.Laryngoscope investigative otolaryngology · 2022Review
- Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure.International journal of oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Francesca BraviBranch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.ORCID https://orcid.org/0000-0003-0173-5319
Yuan-Chin Amy LeeDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, UT, USA.
Mia HashibeDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0002-6903-2049
Paolo BoffettaStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.ORCID https://orcid.org/0000-0002-3811-2791
David I ConwaySchool of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0001-7762-4063
Monica FerraroniBranch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.ORCID https://orcid.org/0000-0002-4542-4996
Carlo La VecchiaBranch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.ORCID https://orcid.org/0000-0003-1441-897X
Valeria EdefontiBranch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.ORCID https://orcid.org/0000-0002-1995-1477
INHANCE Consortium investigators
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUCLA SPORE IN LUNG CANCERP50CA090388 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2001 to 2008
$13.0MUDP GLUCURONOSYLTRANSFERASES, DETOXIFICATION OF NNKP01CA068384 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LAZARUS, PHILIP · 1995 to 2005
$8.5MUCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3MThe Boston Collaborative Oral Cancer StudyR01CA078609 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1999 to 2010
$5.3MLUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERSU01CA096134 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAO, JENNY T · 2002 to 2007
$5.1MGene Environment Interaction in Head and Neck CancerR01CA090731 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI OLSHAN, ANDREW · 2001 to 2005
$4.6MUDPGLUCURONOSYLTRANSFERASE GENOTYPE AND ORAL CANCER RISKR01DE013158 · NIDCR · UNIVERSITY OF SOUTH FLORIDA · PI LAZARUS, PHILIP · 2000 to 2011
$3.6MThe Oral Microbiome and Upper Aerodigestive Squamous Cell CancerR01CA159036 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AHN, JIYOUNG, HAYES, RICHARD BERNARD · 2011 to 2024
$3.5MPatterns of Somatic Gene Alterations in Oral CancerR01CA100679 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 2004 to 2012
$2.6MOral HPV Infection in HIV-Infected Men and WomenR01DE016631 · NIDCR · OHIO STATE UNIVERSITY · PI GILLISON, MAURA L · 2005 to 2008
$2.5MSeroepidemiologic Study of HPV and Oral CancerR01DE013110 · NIDCR · UNIVERSITY OF IOWA · PI SMITH, ELAINE M. · 1999 to 2003
$2.5MAlper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer CenterEuropean Commission IC15- CT98-0332European Commission IC18-CT97-0222European Community (5th Framework Programme) QLK1-CT-2001-00182FIC NIH HHS R03 TW001500Fondation ARC pour la Recherche sur le CancerFondation de France 01GB9702/3Fondation pour la Recherche Médicale (FRM)Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government BAE 01/5013Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government FIS 97/0024Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government FIS 97/0662Fondo para la Investigacion Cientifica y Tecnologica Argentina (FONCYT)French Agency for Food, Environmental and Occupational Health and Safety (ANSES)French Institute for Public Health Surveillance (InVS)French Ministry of HealthFrench Ministry of LabourFrench National Cancer Institute (INCA)French National Research Agency (ANR)Fribourg League against Cancer FOR381.88Fundação de Amparo à Pesquisa no Estado de São Paulo (FAPESP) 01/01768-2Fundação de Amparo à Pesquisa no Estado de São Paulo (FAPESP) 10/51168-0Fundação de Amparo à Pesquisa no Estado de São Paulo (FAPESP) GENCAPO 04/12054-9German Ministry of Education and ResearchGustave-Roussy Institute 88D28Institut Hospital del Mar d'Investigacions Mediquès (IMIM)International Union Against Cancer (UICC)Italian Association for Research on Cancer (AIRC) 10068Italian Foundation for Cancer Research (FIRC)Italian League against CancerItalian Ministry of Education X8YCBNItalian Ministry of ResearchJohns Hopkins Richard Gelb Cancer Prevention AwardMinistry of Science, Research and Arts Baden-WurttembergNational Cancer Institute (NCI) R01-CA90731 and the Intramural Research ProgramNational Cancer Institute (NCI) R03CA113157National Institute of Dental and Craniofacial Research (NIDCR) R01DE011979National Institute of Dental and Craniofacial Research (NIDCR) R01DE013110National Institute of Dental and Craniofacial Research (NIDCR) R03DE016611National Institute of Environmental Health Sciences (NIEHS) P30ES010126National Institutes of Health (NIH) DE016631 and the Intramural Research ProgramNational Institutes of Health (NIH) K07CA104231National Institutes of Health (NIH) P01CA068384National Institutes of Health (NIH) P50CA090388National Institutes of Health (NIH) R01CA030022National Institutes of Health (NIH) R01CA048996National Institutes of Health (NIH) R01CA051845National Institutes of Health (NIH) R01CA061188National Institutes of Health (NIH) R01CA078609National Institutes of Health (NIH) R01CA100679National Institutes of Health (NIH) R01DA011386National Institutes of Health (NIH) R01DE012609National Institutes of Health (NIH) R01DE013158National Institutes of Health (NIH) R03CA077954National Institutes of Health (NIH) R21ES011667National Institutes of Health (NIH) T32CA009142National Institutes of Health (NIH) TW001500National Institutes of Health (NIH) U01CA096134NCI NIH HHS K07 CA104231NCI NIH HHS P01 CA068384NCI NIH HHS P50 CA090388NCI NIH HHS R01 CA030022NCI NIH HHS R01 CA048996NCI NIH HHS R01 CA078609NCI NIH HHS R01 CA090731NCI NIH HHS R01 CA100679NCI NIH HHS R01 CA159036NCI NIH HHS R03 CA077954NCI NIH HHS R03 CA113157NCI NIH HHS T32 CA009142NCI NIH HHS U01 CA096134NIDA NIH HHS R01 DA011386NIDCR NIH HHS R01 DE013110NIDCR NIH HHS R01 DE013158NIDCR NIH HHS R01 DE016631NIDCR NIH HHS R03 DE016611NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R21 ES011667Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan 17015052Swiss Cancer Research AKT 617The Swiss Research against cancer/Oncosuisse KFS1096-09-2000The Swiss Research against cancer/Oncosuisse KFS-700The Swiss Research against cancer/Oncosuisse OCS-1633Third-Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labor and Welfare of Japan H20-002Università degli Studi di Milano: "Young Investigator Grant Program 2017" to Valeria EdefontiVeterans Affairs Merit Review FundsWorld Cancer Research FundYamagiwa-Yoshida Memorial International Cancer Study Grant
Abstract
objectiveTo summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. SUBJECTS AND
methodsINHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview.
resultsSeventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively.
conclusionsThe number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.
Indexed as
Head and Neck NeoplasmsNeoplasm Recurrence, LocalCase-Control StudiesHumansRisk FactorsTobacco Usehead and neck cancerINHANCElaryngeal canceroral cavity cancerpooled analysisprognostic factorsrisk factors
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