Evidence map›Paper›PMID 32569404›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2021

Bronchopulmonary dysplasia predicted at birth by artificial intelligence.

Henrik Verder, Christian Heiring, Rangasamy Ramanathan, Nikolaos Scoutaris, Povl Verder, Torben E Jessen, Agnar Höskuldsson, Lars Bender, Marianne Dahl, Christian Eschen and 4 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  4. Artificial intelligence and digital technologies transforming neonatal respiratory assessment: a scoping review.Journal of perinatology : official journal of the California Perinatal Association · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Henrik VerderDepartment of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.ORCID 0000-0002-5292-9394
Christian HeiringDepartment of Neonatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Rangasamy RamanathanDepartment of Pediatrics, Division of Neonatology, LAC+USC Medical Center & PH Good Samaritan Hospital, Los Angeles, CA, USA.
Nikolaos ScoutarisDepartment of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
Povl VerderDepartment of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
Torben E JessenDepartment of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
Agnar HöskuldssonDepartment of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
Lars BenderDepartment of Paediatrics, Aalborg Hospital, University of Aalborg, Aalborg, Denmark.
Marianne DahlDepartment of Paediatrics, Odense Hospital, University of Southern Denmark, Odense, Denmark.
Christian EschenDepartment of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
Jesper Fenger-GrønDepartment of Paediatrics, Kolding Hospital, University of Southern Denmark, Kolding, Denmark.
Jes ReinholdtDepartment of Paediatrics, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Heidi SmedegaardDepartment of Paediatrics, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Peter SchousboeDepartment of Pediatrics, Holbaek University Hospital, Holbaek, Denmark.
Holbæk Sygehus · DKUniversity of Copenhagen · DKUniversity of Southern Denmark · DKAalborg University Hospital · DKLAC+USC Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo develop a fast bedside test for prediction and early targeted intervention of bronchopulmonary dysplasia (BPD) to improve the outcome.

methodsIn a multicentre study of preterm infants with gestational age 24-31 weeks, clinical data present at birth were combined with spectral data of gastric aspirate samples taken at birth and analysed using artificial intelligence. The study was designed to develop an algorithm to predict development of BPD. The BPD definition used was the consensus definition of the US National Institutes of Health: Requirement of supplemental oxygen for at least 28 days with subsequent assessment at 36 weeks postmenstrual age.

resultsTwenty-six (43%) of the 61 included infants developed BPD. Spectral data analysis of the gastric aspirates identified the most important wave numbers for classification and surfactant treatment, and birth weight and gestational age were the most important predictive clinical data. By combining these data, the resulting algorithm for early diagnosis of BPD had a sensitivity of 88% and a specificity of 91%.

conclusionA point-of-care test to predict subsequent development of BPD at birth has been developed using a new software algorithm allowing early targeted intervention of BPD which could improve the outcome.

Indexed as

Bronchopulmonary DysplasiaPulmonary SurfactantsArtificial IntelligenceFemaleGestational AgeHumansInfantInfant, NewbornInfant, PrematurePregnancyRespiration, ArtificialPulmonary Surfactantsbronchopulmonary dysplasiachorioamnionitisrespiratory distress syndromespectroscopysurfactant

Identifiers

PMID32569404
PMCPMC7891330
OpenAlexW3036354450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.