ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Prospective Validation of PREDICT and Its Impact on the Transesophageal Echocardiography Use in Management of Staphylococcus aureus Bacteremia.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05522764 (Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity), which is not on this map. Cited by 14 papers.
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Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- BACT-URIE: A Novel Score Integrating Bacteriuria to Predict Infective Endocarditis in Patients WithOpen forum infectious diseases · 2026Article
- Interpreting Blood Culture Results as Early Guidance for Infective Endocarditis.JAMA network open · 2025Article
- Correlation Between Blood Culture Time to Positivity and Vegetation Size inAntibiotics (Basel, Switzerland) · 2025Article
- A comparative analysis between transthoracic and transesophageal echocardiography in screening for infective endocarditis in patients withProceedings (Baylor University. Medical Center) · 2025Article
- Current management ofFujita medical journal · 2024Article
- Sequential Time to Positivity as a Prognostic Indicator inOpen forum infectious diseases · 2024Article
- Prevalence of Infective Endocarditis among Patients withMicroorganisms · 2024Article
- Retrospective Evaluation of the Association of Oxacillin MIC on Acute Treatment Outcomes with Cefazolin and Antistaphylococcal Penicillins in Methicillin-Susceptible Staphylococcus aureus Bacteremia.Journal of clinical microbiology · 2023Article
- Point-of-Care Ultrasound (POCUS) as an Extension of the Physical Examination in Patients with Bacteremia or Candidemia.Journal of clinical medicine · 2022Article
- Prediction Rules for Ruling Out Endocarditis in Patients With Staphylococcus aureus Bacteremia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Unreliability of Clinical Prediction Rules to Exclude without Echocardiography Infective Endocarditis inJournal of clinical medicine · 2022Article
- One Scoring System Does Not Fit All Healthcare Settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- The LAUsanneFrontiers in cardiovascular medicine · 2022Article
- Short time to blood culture positivity in Enterococcus faecalis infective endocarditis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Observational
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundInfective endocarditis (IE) is the most feared complication of Staphylococcus aureus bacteremia (SAB). Transesophageal echocardiogram (TEE) is generally recommended for all patients with SAB; however, supporting data for this are limited. We previously developed a scoring system, "PREDICT," that quantifies the risk of IE and identifies patients who would most benefit most from undergoing TEE. The current prospective investigation aims to validate this score.
methodsWe prospectively screened all consecutive adults (≥18 years) hospitalized with SAB at 3 Mayo Clinic sites between January 2015 and March 2017.
resultsOf 220 patients screened, 199 with SAB met study criteria and were included in the investigation. Of them, 23 (11.6%) patients were diagnosed with definite IE within 12 weeks of initial presentation based on modified Duke's criteria. Using the previously derived PREDICT model, the day 1 score of ≥4 had a sensitivity of 30.4% and a specificity of 93.8%, whereas a day 5 score of ≤2 had a sensitivity and negative-predictive value of 100%. Additional factors including surgery or invasive procedure in the past 30 days, prosthetic heart valve, and higher number of positive blood culture bottles in the first set of cultures were associated with increased risk of IE independent of the day 5 risk score.
conclusionsWe validated the previously developed PREDICT scoring tools for stratifying risk of IE, and the need for undergoing a TEE, among cases of SAB. We also identified other factors with predictive potential, although larger prospective studies are needed to further evaluate possible enhancements to the current scoring system.
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