ArticlePloS one2020
The genetic profile of elite youth soccer players and its association with power and speed depends on maturity status.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Socceromics: A Systematic Review of Omics Technologies to Optimize Performance and Health in Soccer.International journal of molecular sciences · 2026Pooled it
- Differences in Sprinting and Jumping Performance Between Maturity Status Groups in Youth: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- BDNF coexpresses with MTOR and is associated with muscle fiber size, lean mass and power-related traits.European journal of applied physiology · 2025Article
- Brain-derived neurotrophic factor gene polymorphism rs6265 and elite athlete status in four independent populations.Biology of sport · 2025Article
- Air Pollution and Its Impact on Health and Performance in Football Players.Sports (Basel, Switzerland) · 2025Review
- Injury Prevention Strategies in Female Football Players: Addressing Sex-Specific Risks.Sports (Basel, Switzerland) · 2025Review
- The Role of Collagen Genetic Variability in Degenerative Disc Disease and Related Conditions.Current genomics · 2025Review
- Testing in Football: A Narrative Review.Sports (Basel, Switzerland) · 2024Review
- Influence of genetic polymorphism on sports talent performance versus non-athletes: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2024Article
- Article
- The relationships between ACTN3 rs1815739 and PPARA-α rs4253778 gene polymorphisms and athletic performance characteristics in professional soccer players.BMC sports science, medicine & rehabilitation · 2023Article
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- Article
- Genes and Athletic Performance: The 2023 Update.Genes · 2023Review
- Tensiomyographic Assessment of Contractile Properties in Elite Youth Soccer Players According to Maturity Status.Journal of human kinetics · 2023Article
- VEGFA rs2010963 GG genotype is associated with superior adaptations to resistance versus endurance training in the same group of healthy, young men.Molecular genetics and genomics : MGG · 2023Article
- Genetic Variations between Youth and Professional Development Phase English Academy Football Players.Genes · 2022Article
- Influence of Alpha-Actinin-3 R577X Polymorphism on Muscle Damage and the Inflammatory Response after an Acute Strength Training Session.BioMed research international · 2022Article
- Article
- Genetic profile in genes associated with muscle injuries and injury etiology in professional soccer players.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association of multiple single nucleotide polymorphisms (SNPs) with athlete status and power/speed performance in elite male youth soccer players (ESP) and control participants (CON) at different stages of maturity. ESP (n = 535; aged 8-23 years) and CON (n = 151; aged 9-26 years) were genotyped for 10 SNPs and grouped according to years from predicted peak-height-velocity (PHV), i.e. pre- or post-PHV, to determine maturity status. Participants performed bilateral vertical countermovement jumps, bilateral horizontal-forward countermovement jumps, 20m sprints and modified 505-agility tests. Compared to CON, pre-PHV ESP demonstrated a higher ACTN3 (rs1815739) XX ('endurance') genotype frequency distribution, while post-PHV ESP revealed a higher frequency distribution of the PPARA (rs4253778) C-allele, AGT (rs699) GG genotype and NOS3 (rs2070744) T-allele ('power' genotypes/alleles). BDNF (rs6265) CC, COL5A1 (rs12722) CC and NOS3 TT homozygotes sprinted quicker than A-allele carriers, CT heterozygotes and CC homozygotes, respectively. COL2A1 (rs2070739) CC and AMPD1 (rs17602729) GG homozygotes sprinted faster than their respective minor allele carrier counterparts in CON and pre-PHV ESP, respectively. BDNF CC homozygotes jumped further than T-allele carriers, while ESP COL5A1 CC homozygotes jumped higher than TT homozygotes. To conclude, we have shown for the first time that pre- and post-PHV ESP have distinct genetic profiles, with pre-PHV ESP more suited for endurance, and post-PHV ESP for power and speed (the latter phenotypes being crucial attributes for post-PHV ESP). We have also demonstrated that power, acceleration and sprint performance were associated with five SNPs, both individually and in combination, possibly by influencing muscle size and neuromuscular activation.
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