Evidence map›Paper›PMID 32569241›Full record

ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2020

Medications for Children Receiving Intensive Care: A National Sample.

Julia A Heneghan, Eduardo A Trujillo Rivera, Qing Zeng-Treitler, Farhana Faruqe, Hiroki Morizono, James E Bost, Murray M Pollack, Anita K Patel

Open access · greenAbstract read
In one paragraph

Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Association of Laboratory Test Abnormalities With Mortality Risk in Pediatric Intensive Care.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2021
    Article
  8. Severity Trajectories of Pediatric Inpatients Using the Criticality Index.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Julia A HeneghanDivision of Critical Care Medicine, Department of Pediatrics, Children's National Health System and George Washington University School of Medicine and Health Sciences, Washington, DC.
Eduardo A Trujillo RiveraBiomedical Informatics Center, George Washington University School of Medicine and Health Sciences, Washington, DC.
Qing Zeng-TreitlerBiomedical Informatics Center, George Washington University School of Medicine and Health Sciences, Washington, DC.
Farhana FaruqeChildren's National Health System, Washington, DC.
Hiroki MorizonoDepartment of Genomics and Precision Medicine, Center for Genetic Medicine, Children's National Health System and George Washington University School of Medicine and Health Sciences, Washington, DC.
James E BostChildren's National Health System, Washington, DC.
Murray M PollackDivision of Critical Care Medicine, Department of Pediatrics, Children's National Health System and George Washington University School of Medicine and Health Sciences, Washington, DC.
Anita K PatelDivision of Critical Care Medicine, Department of Pediatrics, Children's National Health System and George Washington University School of Medicine and Health Sciences, Washington, DC.
Children's National · USGeorge Washington University · US

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876
6 · The paper itself

Abstract

objectiveTo examine medication administration records through electronic health record data to provide a broad description of the pharmaceutical exposure of critically ill children.

designRetrospective cohort study using the Cerner Health Facts database.

settingUnited States. PATIENTS: A total of 43,374 children 7 days old to less than 22 years old receiving intensive care with available pharmacy data.

interventionsNone. MEASUREMENTS AND MAIN

resultsA total of 907,440 courses of 1,080 unique medications were prescribed with a median of nine medications (range, 1-99; 25-75th percentile, 5-16) per patient. The most common medications were acetaminophen, ondansetron, and morphine. Only 45 medications (4.2%) were prescribed to more than 5% of patients, and these accounted for 442,067 (48.7%) of the total courses of medications. Each additional medication was associated with increased univariate risk of mortality (odds ratio, 1.05; 95% CI, 1.05-1.06; p < 0.001).

conclusionsChildren receiving intensive care receive a median of nine medications per patient and one quarter are prescribed at least than 16 medications. Only 45 medications were prescribed to more than 5% of patients, but these accounted for almost half of all medication courses.

Indexed as

Pharmaceutical PreparationsAdultChildCritical CareElectronic Health RecordsHumansOdds RatioRetrospective StudiesUnited StatesYoung AdultPharmaceutical Preparations

Identifiers

PMID32569241
PMCPMC7483286
OpenAlexW3036765974

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.