ArticleEmerging infectious diseases2020
Rickettsioses as Major Etiologies of Unrecognized Acute Febrile Illness, Sabah, East Malaysia.
Article in Emerging infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Clinical and Laboratory Features of Scrub Typhus among Adult Patients with Acute Febrile Illness in Tak and Nakhon Phanom Provinces, Thailand, 2017-2020.The American journal of tropical medicine and hygiene · 2026Article
- Genotype Analysis onTropical medicine and infectious disease · 2025Article
- Rickettsioses Seropositivity in Malaysia: A Six-Year Trend, 2016-2021.Tropical medicine and infectious disease · 2025Article
- First Report on the Molecular Detection and Characterization ofVeterinary sciences · 2025Article
- Identification of Bacteria and Viruses Associated with Patients with Acute Febrile Illness in Khon Kaen Province, Thailand.Viruses · 2024Article
- Health facility-based prevalence of typhoid fever, typhus and malaria among individuals suspected of acute febrile illnesses in Southwest Region, Ethiopia.Frontiers in epidemiology · 2024Article
- Comprehensive diagnostic testing identifies diverse aetiologies of acute febrile illness among hospitalised children and adults in Sri Lanka: a prospective cohort study.BMJ public health · 2023Article
- Geographical distribution of scrub typhus and risk of Orientia tsutsugamushi infection in Indonesia: Evidence mapping.PLoS neglected tropical diseases · 2023Review
- Habitat and Season Drive Chigger Mite Diversity and Abundance on Small Mammals in Peninsular Malaysia.Pathogens (Basel, Switzerland) · 2022Article
- Rickettsiosis in Southeast Asia: Summary for International Travellers during the COVID-19 Pandemic.Tropical medicine and infectious disease · 2022Review
- An Update on the Laboratory Diagnosis ofPathogens (Basel, Switzerland) · 2021Review
- Spotted fever diagnosis: Experience from a South Indian center.Pathogens and global health · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
Orientia tsutsugamushi, spotted fever group rickettsioses, and typhus group rickettsioses (TGR) are reemerging causes of acute febrile illness (AFI) in Southeast Asia. To further delineate extent, we enrolled patients >4 weeks of age with nonmalarial AFI in Sabah, Malaysia, during 2013-2015. We confirmed rickettsioses (past or acute, IgG titer >160) in 126/354 (36%) patients. We confirmed acute rickettsioses (paired 4-fold IgG titer rise to >160) in 38/145 (26%) patients: 23 O. tsutsugamushi, 9 spotted fever group, 4 TGR, 1 O. tsutsugamushi/spotted fever group, and 1 O. tsutsugamushi/TGR. PCR results were positive in 11/319 (3%) patients. Confirmed rickettsioses were more common in male adults; agricultural/plantation work and recent forest exposure were risk factors. Dizziness and acute hearing loss but not eschars were reported more often with acute rickettsioses. Only 2 patients were treated with doxycycline. Acute rickettsioses are common (>26%), underrecognized, and untreated etiologies of AFI in East Malaysia; empirical doxycycline treatment should be considered.
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