Evidence map›Paper›PMID 32568416›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2020

A Drug Holiday Reduces the Frequency and Severity of Medication-Related Osteonecrosis of the Jaw in a Minipig Model.

Sven Otto, Christoph Pautke, Daniel Arens, Philipp Poxleitner, Ursula Eberli, Dirk Nehrbass, Stephan Zeiter, Martin J Stoddart

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Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sven OttoDepartment of Oral and Maxillofacial Surgery, Ludwig Maximilians University, Munich, Germany.
Christoph PautkeDepartment of Oral and Maxillofacial Surgery, Ludwig Maximilians University, Munich, Germany.ORCID 0000-0003-2857-3524
Daniel ArensAO Research Institute Davos, Davos, Switzerland.
Philipp PoxleitnerDepartment of Oral and Maxillofacial Surgery, Albert-Ludwigs-University, Freiburg, Germany.
Ursula EberliAO Research Institute Davos, Davos, Switzerland.
Dirk NehrbassAO Research Institute Davos, Davos, Switzerland.
Stephan ZeiterAO Research Institute Davos, Davos, Switzerland.
Martin J StoddartAO Research Institute Davos, Davos, Switzerland.ORCID 0000-0002-9538-1517

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of medication-related osteonecrosis of the jaw (MRONJ) is challenging and no clear consensus has been achieved. This study investigated preventive measures recommended for tooth extractions under antiresorptive (AR) treatment and the role of discontinuation of AR therapy to avoid the onset of MRONJ in a minipig model. Thirty-six Göttingen minipigs were divided into four groups. Group 1 (negative control): tooth extractions but no zoledronate (ZOL). Group 2 (positive control): weekly ZOL infusions for 12 weeks followed by tooth extractions without wound management followed by 8 weeks of ZOL treatment. Group 3: weekly ZOL infusions for 12 weeks followed by tooth extractions; surgical wound management (resection of sharp bone edges, mucoperiosteal coverage); and continuation of ZOL infusions for 8 weeks plus antibiotic treatment. Group 4: 12 weeks of ZOL infusions followed by a drug holiday for 6 weeks. Tooth extractions with preventive wound management followed by antibiotic treatment for 8 weeks but no ZOL infusions. Jawbones were subjected to macroscopic, radiological (CT and micro-CT) and histopathological investigations. No clinical cases of MRONJ were observed in the negative group, in the positive control all animals developed MRONJ. Group 3 developed MRONJ in 83% of cases. With a drug holiday, 40% developed MRONJ in areas of tooth extraction. This is the first large animal model that reduces the occurrence of MRONJ following tooth extraction by the implementation of a drug holiday combined with antibiotic prophylaxis and smoothening of sharp bony edges. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research..

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsPharmaceutical PreparationsAnimalsDiphosphonatesSwineSwine, MiniatureZoledronic AcidBone Density Conservation AgentsDiphosphonatesPharmaceutical PreparationsZoledronic AcidANIMAL MODELBISPHOSPHONATESBRONJMINIPIGMRONJOSTEONECROSISPREVENTIONPROPHYLAXISZOLEDRONATE

Identifiers

PMID32568416
PMCPMC7689727

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.