Evidence map›Paper›PMID 32568212›Full record

ArticleJournal of Alzheimer's disease : JAD2020

Maximizing Safety in the Conduct of Alzheimer's Disease Fluid Biomarker Research in the Era of COVID-19.

Suzanne E Schindler, Gregory A Jicha, Peter T Nelson, C Dirk Keene, Kaj Blennow, José Luis Molinuevo, Colin L Masters, Oskar Hansson, Charlotte E Teunissen, Douglas Galasko and 3 more

Abstract readLetter
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Suzanne E SchindlerDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Gregory A JichaDepartment of Neurology, University of Kentucky, Lexington, KY, USA.
Peter T NelsonSanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
C Dirk KeeneDepartment of Pathology, University of Washington, Seattle, WA, USA.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University Gothenburg, Mölndal, Sweden.
José Luis MolinuevoBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
Colin L MastersThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.
Oskar HanssonDepartment of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden.
Charlotte E TeunissenDepartment of Clinical Chemistry, Neurochemistry Laboratory and Biobank, Amsterdam Neuroscience, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Douglas GalaskoDepartment of Neurology, University of California, San Diego, CA, USA.
Leslie M ShawDepartment of Pathology and Laboratory Medicine, and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, USA.
Allan I LeveyDepartment of Neurology and Goizueta Alzheimer Disease Research Center, Emory University, Atlanta, GA, USA.
Nina SilverbergDivision of Neuroscience, National Institute on Aging, Bethesda, MD, USA.

Funding

STAGING PRECLINICAL AD WITH CSF BIOMARKERSK23AG053426 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2017 to 2020
$654k
NIA NIH HHS K23 AG053426
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic led to an abrupt halt of many Alzheimer's disease (AD) research studies at sites spanning the world. This is especially true for studies requiring in-person contact, such as studies collecting biofluids. Since COVID-19 is likely to remain a threat for an extended period, the resumption of fluid biomarker studies requires the development and implementation of procedures that minimize the risk of in-person visits to participants, staff, and individuals handling the biofluid samples. Some issues to consider include structuring the visit workflow to minimize contacts and promote social distancing; screening and/or testing participants and staff for COVID-19; wearing masks and performing hand hygiene; and precautions for handling, storing, and analyzing biofluids. AD fluid biomarker research remains a vitally important public health priority and resuming studies requires appropriate safety procedures to protect research participants and staff.

Indexed as

BetacoronavirusPatient SafetyPersonal Protective EquipmentAlzheimer DiseaseBiomarkersBody FluidsCoronavirus InfectionsCOVID-19Health PersonnelHumansPandemicsPneumonia, ViralSARS-CoV-2BiomarkersAlzheimer’s diseasebiofluidsbiomarkersCOVID-19safety

Identifiers

PMID32568212
PMCPMC7995336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.