Evidence map›Paper›PMID 32568069›Full record

ArticleeLife2020

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission.

Aurélia C Balestra, Mohammad Zeeshan, Edward Rea, Carla Pasquarello, Lorenzo Brusini, Tobias Mourier, Amit Kumar Subudhi, Natacha Klages, Patrizia Arboit, Rajan Pandey and 8 more

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. DivergentLife science alliance · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. The molecular mechanisms driving Plasmodium cell division.Biochemical Society transactions · 2024
    Review
  10. Article
  11. Article
  12. mBio · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Microbiology spectrum · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Aurélia C Balestra *University of Geneva, Faculty of Medicine, Geneva, Switzerland.
Mohammad Zeeshan *University of Nottingham, School of Life Sciences, Nottingham, United Kingdom.
Edward Rea *University of Nottingham, School of Life Sciences, Nottingham, United Kingdom.
Carla Pasquarello *University of Geneva, Faculty of Medicine, Geneva, Switzerland.
Lorenzo BrusiniUniversity of Geneva, Faculty of Medicine, Geneva, Switzerland.
Tobias MourierBiological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Amit Kumar SubudhiBiological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Natacha KlagesUniversity of Geneva, Faculty of Medicine, Geneva, Switzerland.
Patrizia ArboitUniversity of Geneva, Faculty of Medicine, Geneva, Switzerland.
Rajan PandeyUniversity of Nottingham, School of Life Sciences, Nottingham, United Kingdom.
Declan BradyUniversity of Nottingham, School of Life Sciences, Nottingham, United Kingdom.
Sue VaughanOxford Brookes University, Department of Biological and Medical Sciences, Oxford, United Kingdom.
Anthony A HolderThe Francis Crick Institute, Malaria Parasitology Laboratory, London, United Kingdom.ORCID 0000-0002-8490-6058
Arnab PainBiological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
David Jp FergusonOxford Brookes University, Department of Biological and Medical Sciences, Oxford, United Kingdom.ORCID 0000-0001-5045-819X
Alexandre HainardUniversity of Geneva, Faculty of Medicine, Geneva, Switzerland.
Rita Tewari *University of Nottingham, School of Life Sciences, Nottingham, United Kingdom.ORCID 0000-0003-3943-1847
Mathieu Brochet *University of Geneva, Faculty of Medicine, Geneva, Switzerland.ORCID 0000-0003-3911-5537

Funding

Biotechnology and Biological Sciences Research Council BB/N017609/1Cancer Research UK FC010097Medical Research Council FC010097Medical Research Council G0900109Medical Research Council G0900278Medical Research Council MR/K011782/1Medical Research Council MR/N023048/1Wellcome TrustWellcome Trust FC010097
6 · The paper itself

Abstract

Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdependency. We show that

Indexed as

Signal TransductionCyclin-Dependent Kinase 5MalariaPlasmodium bergheiProtozoan ProteinsCyclin-Dependent Kinase 5Protozoan Proteinscell cyclecyclin-dependent kinaseDNA replicationgametogenesisinfectious diseasemicrobiologyPlasmodiumtransmission

Identifiers

PMID32568069
PMCPMC7308089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.