ArticleeLife2020
The caudate nucleus contributes causally to decisions that balance reward and uncertain visual information.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Effects of rTMS intervention on resting-state functional brain activityin children with autism spectrum disorders: a resting-state fMRI study.BMC pediatrics · 2026Trial
- Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys.eLife · 2026Article
- A corticostriatal circuit updates subjective beliefs about latent task states.bioRxiv : the preprint server for biology · 2026Article
- Efficient Inference in First Passage Time Models.Statistics and computing · 2026Article
- A novel approach-avoidance task to study decision making under outcome uncertainty.Psychonomic bulletin & review · 2026Article
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Fragmented learning from short videos modulates neural activity and connectivity during memory retrieval.NPJ science of learning · 2026Article
- Effects of light on brain-state dynamics and energy landscape.Network neuroscience (Cambridge, Mass.) · 2026Article
- Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys.bioRxiv : the preprint server for biology · 2025Article
- How cortico-basal ganglia-thalamic subnetworks can shift decision policies to increase reward rate.PLoS computational biology · 2025Article
- Evaluation of MRI-based brain oxygen extraction fraction mapping in patients with systemic lupus erythematosus.Lupus science & medicine · 2025Article
- Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors.Journal of mood and anxiety disorders · 2025Article
- Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.International journal of molecular sciences · 2025Review
- Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.Nature human behaviour · 2025Article
- A population representation of the confidence in a decision in the parietal cortex.Cell reports · 2025Article
- A Population Representation of the Confidence in a Decision in the Parietal Cortex.bioRxiv : the preprint server for biology · 2025Article
- Basal ganglia components have distinct computational roles in decision-making dynamics under conflict and uncertainty.PLoS biology · 2025Article
- Article
- The brain's first "traffic map" through Unified Structural and Functional Connectivity (USFC) modeling.Communications biology · 2024Article
- Bats as instructive animal models for studying longevity and aging.Annals of the New York Academy of Sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Our decisions often balance what we observe and what we desire. A prime candidate for implementing this complex balancing act is the basal ganglia pathway, but its roles have not yet been examined experimentally in detail. Here, we show that a major input station of the basal ganglia, the caudate nucleus, plays a causal role in integrating uncertain visual evidence and reward context to guide adaptive decision-making. In monkeys making saccadic decisions based on motion cues and asymmetric reward-choice associations, single caudate neurons encoded both sources of information. Electrical microstimulation at caudate sites during motion viewing affected the monkeys' decisions. These microstimulation effects included coordinated changes in multiple computational components of the decision process that mimicked the monkeys' similarly coordinated voluntary strategies for balancing visual and reward information. These results imply that the caudate nucleus plays causal roles in coordinating decision processes that balance external evidence and internal preferences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.