Evidence map›Paper›PMID 32567857›Full record

ArticleJournal of medicinal chemistry2020

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT

Eric A Wold, Erik J Garcia, Christopher T Wild, Joanna M Miszkiel, Claudia A Soto, Jianping Chen, Konrad Pazdrak, Robert G Fox, Noelle C Anastasio, Kathryn A Cunningham and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. The Effect of Serotonin 5-HTAddiction biology · 2025
    Article
  3. Article
  4. Targeting the 5-HTJournal of medicinal chemistry · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. 5-HTNutrients · 2023
    Review
  9. G protein-coupled receptors and obesity.Frontiers in endocrinology · 2023
    Review
  10. Review
  11. Article
  12. Review
  13. Editorial: Contemporary Perspective on 5-HTFrontiers in pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Eric A WoldCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.ORCID 0000-0001-6434-7562
Erik J GarciaCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Christopher T WildCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Joanna M MiszkielCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Claudia A SotoCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.ORCID 0000-0002-5214-9136
Jianping ChenCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Konrad PazdrakCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Robert G FoxCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.
Noelle C AnastasioCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.ORCID 0000-0001-5579-4213
Kathryn A CunninghamCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.ORCID 0000-0002-4257-1739
Jia ZhouCenter for Addiction Research, University of Texas Medical Branch, Galveston, Texas 77555, United States.ORCID 0000-0002-2811-1090
The University of Texas Medical Branch at Galveston · US

Funding

5-HT2 Receptor Allosterism in Cocaine Use DisorderR01DA038446 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Kathryn A. Cunningham, Jia Zhou · 2015 to 2026
$5.3M
Translational Explorations in Substance Use DisordersT32DA007287 · NIDA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Kathryn A. Cunningham, Jonathan Dean Hommel · 1994 to 2026
$4.7M
Core Center for Translational Addiction SciencesP30DA028821 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2009 to 2010
$1.5M
Addiction and the Neuropharmacology of PsychostimulantsK05DA020087 · NIDA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2005 to 2015
$1.3M
Training in Pharmacological SciencesT32GM089657 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HANCOCK, JOHN F · 2010 to 2014
$728k
Optimization of Allosteric Modulators of 5-HT2C ReceptorR21MH093844 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A., ZHOU, JIA · 2012 to 2013
$450k
5-HT2C Receptor PAMs as Neurotherapeutics for Cocaine Use DisorderF31DA045511 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WOLD, ERIC A. · 2018 to 2020
$99k
Developing 5-HT2C Receptor Allosteric Modulators to Treat Cocaine Use DisorderF31DA038922 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WILD, CHRISTOPHER TIMOTHY · 2016 to 2017
$63k
NIDA NIH HHS F31 DA038922NIDA NIH HHS F31 DA045511NIDA NIH HHS K05 DA020087NIDA NIH HHS P30 DA028821NIDA NIH HHS R01 DA038446NIDA NIH HHS T32 DA007287NIGMS NIH HHS T32 GM089657NIMH NIH HHS HHSN271201300017CNIMH NIH HHS R21 MH093844
6 · The paper itself

Abstract

Targeting the serotonin (5-HT) 5-HT

Indexed as

AnimalsBinding SitesCHO CellsCricetulusDrug DesignMolecular Docking SimulationMolecular StructurePiperidinesReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsStructure-Activity RelationshipPiperidinesReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Agonists

Identifiers

PMID32567857
PMCPMC8434884
OpenAlexW3036126238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.