Evidence map›Paper›PMID 32567818›Full record

ArticleInfluenza and other respiratory viruses2020

Respiratory viral coinfection in a birth cohort of infants in rural Nepal.

Anne Emanuels, Stephen E Hawes, Kira L Newman, Emily T Martin, Janet A Englund, James M Tielsch, Jane Kuypers, Subarna K Khatry, Steven C LeClerq, Joanne Katz and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Influenza and other respiratory viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Burden of Respiratory Viruses in Children Less Than 2 Years Old in a Community-based Longitudinal US Birth Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Anne EmanuelsDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3876-1895
Stephen E HawesDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Kira L NewmanDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Emily T MartinUniversity of Michigan, Ann Arbor, MI, USA.
Janet A EnglundDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
James M TielschDepartment of Global Health, George Washington University Milken Institute School of Public Health, Washington, DC, USA.
Jane KuypersDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Subarna K KhatryDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Steven C LeClerqDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Joanne KatzDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Helen Y ChuDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8502-9600
University of Washington · USJohns Hopkins University · USMilken Institute · USSeattle Children's Hospital · USUniversity of Michigan · US

Funding

Prospective Community-Based Study of RSV Risk Factors in Nepalese ChildrenK23AI103105 · NIAID · UNIVERSITY OF WASHINGTON · PI CHU, HELEN YING-HUI · 2013 to 2017
$897k
NIAID NIH HHS K23 AI103105NIH HHS K23-AI103105
6 · The paper itself

Abstract

backgroundAcute respiratory illnesses are a leading cause of global morbidity and mortality in children. Coinfection with multiple respiratory viruses is common. Although the effects of each virus have been studied individually, the impacts of coinfection on disease severity are less understood.

methodsA secondary analysis was performed of a maternal influenza vaccine trial conducted between 2011 and 2014 in Nepal. Prospective weekly household-based active surveillance of infants was conducted from birth to 180 days of age. Mid-nasal swabs were collected and tested for respiratory syncytial virus (RSV), rhinovirus, influenza, human metapneumovirus (HMPV), coronavirus, parainfluenza (HPIV), and bocavirus by RT-PCR. Coinfection was defined as the presence of two or more respiratory viruses detected as part of the same illness episode.

resultsOf 1730 infants with a respiratory illness, 327 (19%) had at least two respiratory viruses detected in their primary illness episode. Of 113 infants with influenza, 23 (20%) had coinfection. Of 214 infants with RSV, 87 (41%) had coinfection. The cohort of infants with coinfection had increased occurrence of fever lasting ≥ 4 days (OR 1.4, 95% CI: 1.1, 2.0), and so did the subset of coinfected infants with influenza (OR 5.8, 95% CI: 1.8, 18.7). Coinfection was not associated with seeking further care (OR 1.1, 95% CI: 0.8, 1.5) or pneumonia (OR 1.2, 95% CI: 0.96, 1.6).

conclusionA high proportion of infants had multiple viruses detected. Coinfection was associated with greater odds of fever lasting for four or more days, but not with increased illness severity by other measures.

Indexed as

CoinfectionFeverHumansInfantInfant, NewbornNepalOdds RatioProspective StudiesRespiratory Tract InfectionsRural PopulationVirus DiseasesVirusescoinfectionepidemiologyglobal healthhuman influenzahuman respiratory syncytial virusrespiratory infections

Identifiers

PMID32567818
PMCPMC7578290
OpenAlexW3035969660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.