Evidence map›Paper›PMID 32567798›Full record

SynthesisInternational forum of allergy & rhinology2020

Treatment of post-viral olfactory dysfunction: an evidence-based review with recommendations.

Nanki Hura, Deborah X Xie, Garret W Choby, Rodney J Schlosser, Cinthia P Orlov, Stella M Seal, Nicholas R Rowan

3 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International forum of allergy & rhinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 66 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04484493 phase3completednot on this map

Role of Corticosteroid Nasal Spray in Recovery of Smell Sensation in COVID-19 Patients

TypeinterventionalSponsorBenha UniversityRan2020 to 2020Enrolled100ConditionsCovid19, AnosmiaArmsmometasone furoate nasal spray
NCT05947643 phase2completednot on this mapstarted 2022, after this paper: background citation

Smell in COVID-19 and Efficacy of Nasal Theophylline 3

TypeinterventionalSponsorWashington University School of MedicineRan2022 to 2025Enrolled77ConditionsCOVID-19Armstheophylline, Placebo
NCT06498687 phase1withdrawnnot on this mapstarted 2025, after this paper: background citation

A Single-Arm Study to Evaluate the Feasibility of CYR-064 Theophylline Nasal Spray for the Treatment of Parkinson's Disease Related Hyposmia and Anosmia

TypeinterventionalSponsorUniversity of NebraskaRan2025 to 2026Enrolled0ConditionsHyposmia, AnosmiaArmsCYR-064
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nanki HuraDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0002-0722-3544
Deborah X XieDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD.
Garret W ChobyDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic College of Medicine, Rochester, MN.ORCID 0000-0002-3745-2727
Rodney J SchlosserDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.
Cinthia P OrlovDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD.
Stella M SealDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD.
Nicholas R RowanDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-1296-2648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-viral olfactory dysfunction (PVOD) is one of the most common causes of olfactory loss. Despite its prevalence, optimal treatment strategies remain unclear. This article provides a comprehensive review of PVOD treatment options and provides evidence-based recommendations for their use.

methodsA systematic review of the Medline, Embase, Cochrane, Web of Science, Scopus, and Google Scholar databases was completed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies with defined olfactory outcomes of patients treated for PVOD following medical, surgical, acupuncture, or olfactory training interventions were included. The Clinical Practice Guideline Development Manual and Conference on Guideline Standardization (COGS) instrument recommendations were followed in accordance with a previously described, rigorous, iterative process to create an evidence-based review with recommendations.

resultsFrom 552 initial candidate articles, 36 studies with data for 2183 patients with PVOD were ultimately included. The most common method to assess olfactory outcomes was Sniffin' Sticks. Broad treatment categories included: olfactory training, systemic steroids, topical therapies, a variety of heterogeneous non-steroidal oral medications, and acupuncture.

conclusionBased on the available evidence, olfactory training is a recommendation for the treatment of PVOD. The use of short-term systemic and/or topical steroids is an option in select patients after careful consideration of potential risks of oral steroids. Though some pharmacological investigations offer promising preliminary results for systemic and topical medications alike, a paucity of high-quality studies limits the ability to make meaningful evidence-based recommendations for the use of these therapies for the treatment of PVOD.

Indexed as

Olfaction DisordersHumansResearch DesignSmellSteroidsSteroidsbudesonideevidence-based medicineolfaction disordersolfactory trainingsmellviral infection

Identifiers

PMID32567798
PMCPMC7361320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.