ArticleThe EMBO journal2020
MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation.
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Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.
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146citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
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Who cites it
146 citing papers in PubMed, 253 citations in OpenAlex.
- SPRIZ (CCDC127) protein conserved in deuterostome animals is a rigid OMM-IMM tether that locally sets mitochondrial IMS volume.Science advances · 2026Article
- Trypanosomal MICOS Is Assembled on Non-Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins.Molecular microbiology · 2026Article
- Integrative structural modelling reveals the human Mic60-Mic19 subcomplex as a diffusion barrier in mitochondria.Nature communications · 2026Article
- The molecular mechanisms of crista formation: how mitochondria give themselves breathing room.Biochemical Society transactions · 2026Review
- Sph-mediated mtDNA release and autophagy-dependent ferroptosis contribute to Staphylococcus aureus-induced mastitis.PLoS pathogens · 2026Article
- The molecular basis of mitochondrial crista formation by the MIC10 complex.Science advances · 2026Article
- Mitochondrial Quality Control Impairment Is a Hallmark of TDP-43Antioxidants (Basel, Switzerland) · 2026Article
- Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling.PLoS biology · 2026Article
- Integrative structure determination of a human mitochondrial contact site and cristae organizing system (MICOS) sub-assembly.bioRxiv : the preprint server for biology · 2026Article
- Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta.Nature communications · 2026Article
- Targeting RuvBL1 disrupts mitochondrial metabolism and structure in hepatocellular carcinoma.JHEP reports : innovation in hepatology · 2026Article
- Higher-order structural organization of mitochondrial metabolism.The Journal of biological chemistry · 2026Review
- Mitochondrial metabolic reprogramming drives diabetic kidney disease progression: cell-specific mechanisms, metabolic memory, and targeted strategies.Molecular medicine (Cambridge, Mass.) · 2026Review
- MICOS and MIMAS, multifunctional assemblies linking mitochondrial biogenesis, architecture, and function.Protein science : a publication of the Protein Society · 2026Review
- Article
- Mitochondrial iron overload is associated with lysosomal dysfunction-mediated mitophagy impairment in the heart of Friedreich's ataxia.Mitochondrion · 2026Article
- Mitochondrial geneTranslational cancer research · 2026Article
- Cristae: bridging bioenergetic hubs and compartmental barriers in mitochondrial homeostasis.Cell death & disease · 2026Review
- Article
- Membranes arrest the coarsening of mitochondrial condensates in human cells.Communications biology · 2026Article
86 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 4 institutions in 1 country.
Till Stephan *Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID 0000-0002-4032-7644
Christian Brüser *Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Markus DeckersDepartment of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany.
Anna M SteyerDepartment of Neurogenetics, Electron Microscopy Core Unit, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Francisco BalzarottiDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Mariam BarbotDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Tiana S BehrDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Gudrun HeimLaboratory of Electron Microscopy, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Wolfgang HübnerDepartment of Physics, University Bielefeld, Bielefeld, Germany.
Peter IlgenDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Felix LangeDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
David Pacheu-GrauDepartment of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany.
Jasmin K PapeDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID 0000-0003-4403-4520
Stefan StoldtDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Thomas HuserDepartment of Physics, University Bielefeld, Bielefeld, Germany.
Stefan W HellDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Wiebke MöbiusDepartment of Neurogenetics, Electron Microscopy Core Unit, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID 0000-0002-2902-7165
Peter RehlingDepartment of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0001-5661-5272
Dietmar RiedelLaboratory of Electron Microscopy, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Stefan JakobsDepartment of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID 0000-0002-8028-3121
Universitätsmedizin Göttingen · DEMax Planck Institute for Biophysical Chemistry · DEBielefeld University · DEMax Planck Institute of Experimental Medicine · DE
Funding
Deutsche Forschungsgemeinschaft (DFG) FOR2848; P08; Z01, SFB1190; P01; P13H2020 European Research Council (ERC) 835102
Abstract
Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. With the MICOS complex, OPA1 and the F
Indexed as
HeLa CellsHumansMembrane Cofactor ProteinMembrane ProteinsMitochondrial MembranesMitochondrial ProteinsMitochondrial Proton-Translocating ATPasesMultiprotein ComplexesCD46 protein, humanF1F0-ATP synthaseMembrane Cofactor ProteinMembrane ProteinsMitochondrial ProteinsMitochondrial Proton-Translocating ATPasesMultiprotein Complexescristae biogenesiselectron microscopyMINFLUXnanoscopysuper-resolution microscopy
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