ArticlePhysiological genomics2020
Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats.
Article in Physiological genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Who cites it
56 citing papers in PubMed, 94 citations in OpenAlex.
- IgG positive food elimination diet altered gut microbiota, decreased zonulin in migraine adults: a pilot dietary intervention trial.Frontiers in nutrition · 2026Trial
- Identify contaminants with decontam on the QIIME 2 Framework.Microbiology resource announcements · 2026Article
- From alpha diversity to zeitgebers: Bacterial gut microbiome associations with sleep and circadian disruption (Part I).Neuroscience and biobehavioral reviews · 2026Review
- From alpha diversity to zeitgebers: Functional implications and potential mechanisms linking the gut microbiome to sleep and circadian disruption (Part II).Neuroscience and biobehavioral reviews · 2026Review
- Analysis of gut microbiota in Restless Legs Syndrome: searching for a metagenomic signature.Sleep · 2026Article
- Inadequate sleep is a risk factor for pediatric hypertension: the pathophysiologic and socioeconomic correlates.Pediatric research · 2026Review
- Sleep fragmentation frequency is associated with distinct immune, microbial, and barrier-related profiles in DSS-induced colitis in mice.Frontiers in immunology · 2026Article
- Gut Microbiota, Immune Phenotypes, and Insomnia: A Two-Sample Mendelian Randomization Study.Nature and science of sleep · 2026Article
- Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment.Gut microbes · 2025Review
- Sleep recovery alleviates impaired glucose tolerance induced by sleep fragmentation possibly through gut microbiota in mice.Scientific reports · 2025Article
- Cross-Sectional Analysis of Sleep Quality and Vascular Health in Shift- and Day-Working Nurses.Clocks & sleep · 2025Article
- The cardiovascular consequences of chronic sleep fragmentation: Evidence from experimental models of obstructive sleep apnea.Sleep medicine · 2025Article
- Better objective sleep quality is associated with higher gut microbiota richness in older adults.GeroScience · 2025Article
- Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances.Animal models and experimental medicine · 2025Article
- Baihe Dihuang Tang as a therapeutic candidate for insomnia: Targeting gut dysbiosis and neuroendocrine dysfunction.iMetaOmics · 2025Article
- How does gut microbiota affect the vaginitis axis? The mediating role of plasma metabolites.Microbiology spectrum · 2025Article
- Second brain: reviewing the gut microbiome's role in lifestyle diseases.Biotechnologia · 2025Review
- Gut microbiota and insomnia: Mendelian randomization and network pharmacology to predict potential intervention with traditional Chinese medicine.Archives of medical science : AMS · 2025Article
- Article
- Recent progresses in gut microbiome mediates obstructive sleep apnea-induced cardiovascular diseases.FASEB bioAdvances · 2024Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The gut microbiota, via the production of metabolites entering the circulation, plays a role in blood pressure regulation. Blood pressure is also affected by the characteristics of sleep. To date, no studies have examined relationships among the gut microbiota/metabolites, blood pressure, and sleep. We hypothesized that fragmented sleep is associated with elevated mean arterial pressure, an altered and dysbiotic gut microbial community, and changes in fecal metabolites. In our model system, rats were randomized to 8 h of sleep fragmentation during the rest phase (light phase) or were undisturbed (controls) for 28 consecutive days. Rats underwent sleep and blood pressure recordings, and fecal samples were analyzed during: baseline (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.