ArticleClinical and translational medicine2020
Contrast-enhanced CT radiomics for preoperative evaluation of microvascular invasion in hepatocellular carcinoma: A two-center study.
Article in Clinical and translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 5 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 5 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Computed tomography-based artificial intelligence for predicting preoperative microvascular invasion in hepatocellular carcinoma: a systematic review and meta-analysis.La Radiologia medica · 2026Pooled it
- Quality of radiomics for predicting microvascular invasion in hepatocellular carcinoma: a systematic review.European radiology · 2023Pooled it
- CT radiomics for prediction of microvascular invasion in hepatocellular carcinoma: A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2023Pooled it
- Radiomics for the Preoperative Evaluation of Microvascular Invasion in Hepatocellular Carcinoma: A Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Diagnostic Accuracy of Artificial Intelligence Based on Imaging Data for Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Influence of different region of interest sizes on CT-based radiomics model for microvascular invasion prediction in hepatocellular carcinoma.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Trial
- Enhanced prediction of microvascular invasion in hepatocellular carcinoma: a comparative study of intraoperative ultrasound, CT imaging and radiomic.La Radiologia medica · 2026Article
- Artificial intelligence-enabled clinical decision support systems in preadmission testing: a scoping review of risk prediction, triage, and perioperative workflows (2020-2025).Journal of clinical monitoring and computing · 2026Article
- 3D fractal dimension analysis of CT imaging for microvascular invasion prediction in hepatocellular carcinoma.European radiology · 2026Article
- Multi-Phasic CECT Peritumoral Radiomics Predict Treatment Response to Bevacizumab-Based Chemotherapy in RAS-Mutated Colorectal Liver Metastases.Bioengineering (Basel, Switzerland) · 2026Article
- Identification of Microvascular Invasion-Related Biomarkers for Personalized Treatment of Hepatocellular Carcinoma.Current medicinal chemistry · 2026Article
- Multiparametric dual-energy computed tomography radiomics for predicting microvascular invasion in hepatocellular carcinoma.BMC medical imaging · 2025Article
- Article
- Joint model based on intratumoral and peritumoral computed tomography radiomics integrated with clinical features for predicting the spread through air spaces in lung adenocarcinoma: a multicenter study.Quantitative imaging in medicine and surgery · 2025Article
- Advances and challenges in pathomics for liver cancer: From diagnosis to prognostic stratification.World journal of clinical oncology · 2025Review
- Histopathologic deep learning model for predicting tumor response to hepatic arterial infusion chemotherapy plus TKIs and ICIs in large hepatocellular carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Preoperative prediction of microvascular invasion and relapse-free survival in hepatocellular Carcinoma ≥3 cm using CT radiomics: Development and external validation.BMC medical imaging · 2025Article
- Radiomics and clinicoradiological factors as a promising approach for predicting microvascular invasion in hepatitis B-related hepatocellular carcinoma.World journal of gastroenterology · 2025Article
- Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma: A retrospective study.World journal of gastrointestinal oncology · 2025Article
- Integrating intratumoral, peritumoral, and clinical features in an ultrasound-based radiomics model: contributions and synergies for predicting microvascular invasion in hepatocellular carcinoma.Frontiers in oncology · 2025Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe present study constructed and validated the use of contrast-enhanced computed tomography (CT)-based radiomics to preoperatively predict microvascular invasion (MVI) status (positive vs negative) and risk (low vs high) in patients with hepatocellular carcinoma (HCC).
methodsWe enrolled 637 patients from two independent institutions. Patients from Institution I were randomly divided into a training cohort of 451 patients and a test cohort of 111 patients. Patients from Institution II served as an independent validation set. The LASSO algorithm was used for the selection of 798 radiomics features. Two classifiers for predicting MVI status and MVI risk were developed using multivariable logistic regression. We also performed a survival analysis to investigate the potentially prognostic value of the proposed MVI classifiers.
resultsThe developed radiomics signature predicted MVI status with an area under the receiver operating characteristic curve (AUC) of .780, .776, and .743 in the training, test, and independent validation cohorts, respectively. The final MVI status classifier that integrated two clinical factors (age and α-fetoprotein level) achieved AUC of .806, .803, and .796 in the training, test, and independent validation cohorts, respectively. For MVI risk stratification, the AUCs of the radiomics signature were .746, .664, and .700 in the training, test, and independent validation cohorts, respectively, and the AUCs of the final MVI risk classifier-integrated clinical stage were .783, .778, and .740, respectively. Survival analysis showed that our MVI status classifier significantly stratified patients for short overall survival or early tumor recurrence.
conclusionsOur CT radiomics-based models were able to predict MVI status and MVI risk of HCC and might serve as a reliable preoperative evaluation tool.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.