Evidence map›Paper›PMID 32567240›Full record

ArticleMacromolecular bioscience2020

Aqueous RAFT Synthesis of Low Molecular Weight Anionic Polymers for Determination of Structure/Binding Interactions with Gliadin.

Ashleigh N Bristol, Brooke P Carpenter, Ashley N Davis, Lisa K Kemp, Vijayaraghavan Rangachari, Shahid Karim, Sarah E Morgan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ashleigh N BristolSchool of Polymer Science and Engineering, 118 College Dr., #5050, The University of Southern Mississippi, Hattiesburg, MS, 39406-5050, USA.
Brooke P CarpenterSchool of Polymer Science and Engineering, 118 College Dr., #5050, The University of Southern Mississippi, Hattiesburg, MS, 39406-5050, USA.
Ashley N DavisSchool of Polymer Science and Engineering, 118 College Dr., #5050, The University of Southern Mississippi, Hattiesburg, MS, 39406-5050, USA.
Lisa K KempSchool of Polymer Science and Engineering, 118 College Dr., #5050, The University of Southern Mississippi, Hattiesburg, MS, 39406-5050, USA.
Vijayaraghavan RangachariDepartment of Chemistry and Biochemistry, The University of Southern Mississippi, Hattiesburg, MS, 39406-5050, USA.
Shahid KarimSchool of Biological, Environmental, and Earth Sciences, 118 College Dr., #5018, The University of Southern Mississippi, Hattiesburg, MS, 39406-5050, USA.
Sarah E MorganSchool of Polymer Science and Engineering, 118 College Dr., #5050, The University of Southern Mississippi, Hattiesburg, MS, 39406-5050, USA.ORCID 0000-0002-8796-9548
University of Southern Mississippi · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Investigating Molecular Assembly and Dynamics of Tick Cement proteinsR15GM123431 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MORGAN, SARAH E · 2017 to 2017
$444k
NIGMS NIH HHS P20 GM103476NIGMS NIH HHS R15 GM123431
6 · The paper itself

Abstract

Gliadin, a component of gluten and a known epitope, is implicated in celiac disease (CeD) and results in an inflammatory response in CeD patients when consumed. Acrylamide-based polyelectrolytes are employed as models to determine the effect of molecular weight and pendent group on non-covalent interaction modes with gliadin in vitro. Poly(sodium 2-acrylamido-2-methylpropane sulfonate) and poly(sodium 3-methylpropyl-3-butanoate) are synthesized via aqueous reversible addition fragmentation chain transfer (aRAFT) polymerization and characterized by gel permeation chromatography-multiangle laser light scattering. The polymer/gliadin blends are examined via circular dichroism, zeta potential measurements, 8-anilinonaphthalene-1-sulfonic acid fluorescence spectroscopy, and dynamic light scattering. Acrylamide polymers containing strong anionic pendent groups have a profound effect on gliadin secondary structure and solution behavior below the isoelectric point, while polymers containing hydrophobic character only have a minor impact. The polymers have little effect on gliadin secondary structure and solution behavior at the isoelectric point.

Indexed as

PolymerizationAcrylamideCircular DichroismDynamic Light ScatteringFluorescenceGliadinHydrogen-Ion ConcentrationMolecular WeightPolymersProton Magnetic Resonance SpectroscopyStatic ElectricityAcrylamideGliadinPolymersanionic polymersaqueous reversible addition fragmentation chain transfereliac diseasegliadinnon-covalent binding

Identifiers

PMID32567240
PMCPMC7520052
OpenAlexW3036848456

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.