Evidence map›Paper›PMID 32567222›Full record

ArticleImmunity, inflammation and disease2020

Fibrogenesis in chronic murine colitis is independent of innate lymphoid cells.

Brecht Creyns, Jonathan Cremer, Gert De Hertogh, Louis Boon, Marc Ferrante, Séverine Vermeire, Gert Van Assche, Jan L Ceuppens, Christine Breynaert

Abstract read
In one paragraph

Article in Immunity, inflammation and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Group 3 innate lymphoid cells in intestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brecht CreynsDepartment of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.ORCID 0000-0002-1634-8875
Jonathan CremerDepartment of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.ORCID 0000-0002-3793-8217
Gert De HertoghDepartment of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium.ORCID 0000-0001-8494-7725
Louis BoonBioceros BV, Utrecht, The Netherlands.ORCID 0000-0002-0937-9171
Marc FerranteDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0000-0003-1492-0716
Séverine VermeireDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0000-0001-9942-3019
Gert Van AsscheDepartment of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0000-0003-0401-4664
Jan L CeuppensDepartment of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.ORCID 0000-0003-4502-2679
Christine BreynaertDepartment of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7368-1068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInsight in the pathogenesis of intestinal fibrosis is an unmet medical need in inflammatory bowel diseases. Studies in murine models and human organ fibrosis point to a potential role of innate lymphoid cells (ILC) in chronic intestinal inflammation and fibrosis. MATERIALS AND

methodsDextran sodium sulfate (DSS) in drinking water was used to induce chronic colitis and remodeling in C57Bl/6 wild type (WT), RAG-deficient, RAG

resultsIn RAG

conclusionThese data argue against a profibrotic effect of ILC in chronic colitis, but rather suggest that ILC have a protective and recovery-enhancing effect after repeated intestinal injury.

Indexed as

ColitisImmunity, InnateAnimalsDextran SulfateFemaleLymphocytesMiceMice, Inbred C57BLDextran SulfateCrohn's diseaseinnate immunityinnate lymphoid cellintestinal fibrosis

Identifiers

PMID32567222
PMCPMC7416052

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.