ArticleJournal of magnetic resonance imaging : JMRI2020
Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases.
Article in Journal of magnetic resonance imaging : JMRI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 57 citations in OpenAlex.
- Regional oxygen extraction fraction is higher in older adults with type 2 diabetes and obesity: associations with cognition and metabolic markers.GeroScience · 2026Article
- Cerebral oxygen extraction fraction as a physiological biomarker in vascular cognitive impairment: A study in older adults enriched for small vessel diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Age dependence of brain oxygen metabolism in adults assessed by 3D constrained quantitative BOLD MRI.NeuroImage · 2026Article
- Association Between Gas-Free Cerebrovascular Reactivity (CVR) and Cognitive Function in Older Adults With a High Risk for Vascular Dementia.Journal of magnetic resonance imaging : JMRI · 2026Article
- Neurovascular and metabolic dysfunction with cell type-specific transcriptomic changes in presymptomatic 5XFAD mice.Fluids and barriers of the CNS · 2026Article
- Cerebral oxygen extraction fraction as an emerging imaging biomarker in mild cognitive impairment and dementia.Dementia & neuropsychologia · 2026Review
- Oxygen extraction fraction is differentially associated with pathological biomarkers in Alzheimer's disease and non-Alzheimer's dementias.Frontiers in neuroscience · 2026Article
- Oxygen extraction fraction mapping between normal cognition and mild cognitive impairment in older adults using quantitative BOLD.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Cerebral oxygen extraction and blood flow in community-based older adults: associations with white matter hyperintensity and neurocognitive function.Brain communications · 2026Article
- Cerebral oxygen extraction across different exercise intensities: Role of arterialExperimental physiology · 2025Article
- Article
- Evaluation of MRI-based brain oxygen extraction fraction mapping in patients with systemic lupus erythematosus.Lupus science & medicine · 2025Article
- Oxygen extraction fraction in small vessel disease: relationship to disease burden and progression.Brain : a journal of neurology · 2025Article
- Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections.Open biology · 2025Review
- Venous arterial spin labeling MRI signal is associated with oxygen supply-independent reduction in cerebral oxygen extraction in typically aging older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial.Cerebral circulation - cognition and behavior · 2025Article
- Research on magnetic resonance imaging in diagnosis of Alzheimer's disease.European journal of medical research · 2024Review
- Quantification of Infarct Core Volume in Patients with Acute Ischemic Stroke Using Cerebral Metabolic Rate of Oxygen in CT Perfusion.AJNR. American journal of neuroradiology · 2024Article
- Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review.Aging medicine (Milton (N.S.W)) · 2024Review
- Elevated cerebral oxygen extraction in patients with post-COVID conditions.NeuroImmune pharmacology and therapeutics · 2024Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlzheimer's disease and vascular cognitive impairment (VCI), as well as their concurrence, represent the most common types of cognitive dysfunction. Treatment strategies for these two conditions are quite different; however, there exists a considerable overlap in their clinical manifestations, and most biomarkers reveal similar abnormalities between these two conditions. PURPOSE: To evaluate the potential of cerebral oxygen extraction fraction (OEF) as a biomarker for differential diagnosis of Alzheimer's disease and VCI. We hypothesized that in Alzheimer's disease OEF will be reduced (decreased oxygen consumption due to decreased neural activity), while in vascular diseases OEF will be elevated (increased oxygen extraction due to abnormally decreased blood flow). STUDY TYPE: Prospective cross-sectional. POPULATION: Sixty-five subjects aged 52-89 years, including 33 mild cognitive impairment (MCI), 7 dementia, and 25 cognitively normal subjects. FIELD STRENGTH/SEQUENCE: 3T T ASSESSMENT: OEF, consensus diagnoses of cognitive impairment, vascular risk factors (such as hypertension, hypercholesterolemia, diabetes, smoking, and obesity), cognitive assessments, and cerebrospinal fluid concentration of amyloid and tau were assessed. STATISTICAL TESTS: Multiple linear regression analyses of OEF with diagnostic category (normal, MCI, or dementia), vascular risks, cognitive performance, amyloid and tau pathology.
resultsWhen evaluating the entire group, OEF was found to be lower with more severe cognitive impairment (β = -2.70 ± 1.15, T = -2.34, P = 0.02), but was higher with greater vascular risk factors (β = 1.36 ± 0.55, T = 2.48, P = 0.02). Further investigation of the subgroup of participants with low vascular risks (N = 44) revealed that lower OEF was associated with worse cognitive performance (β = 0.04 ± 0.01, T = 3.27, P = 0.002) and greater amyloid burden (β = 92.12 ± 41.23, T = 2.23, P = 0.03). Among cognitively impaired individuals (N = 40), higher OEF was associated with greater vascular risk factors (β = 2.19 ± 0.71, T = 3.08, P = 0.004). DATA
conclusionThese findings suggest that OEF is differentially affected by Alzheimer's disease and VCI pathology and may be useful in etiology-based diagnosis of cognitive impairment. LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY: Stage 3 J. MAGN. RESON. IMAGING 2020;52:1829-1837.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.