Evidence map›Paper›PMID 32566931›Full record

ArticleResearch (Washington, D.C.)2020

Magnetic Nanomotor-Based Maneuverable SERS Probe.

Yong Wang, Yuhuan Liu, Yang Li, Dandan Xu, Xi Pan, Yuduo Chen, Dekai Zhou, Bo Wang, Huanhuan Feng, Xing Ma

Abstract read
In one paragraph

Article in Research (Washington, D.C.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. SERS-Based Nano- and Microsystems Toward Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  5. Article
  6. Article
  7. Rapid Blood Clot Removal via Remote Delamination and Magnetization of Clot Debris.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Nanorobots to TreatResearch (Washington, D.C.) · 2024
    Review
  13. Review
  14. Review
  15. Review
  16. Magnetically Actuated Biodegradable Nanorobots for Active Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  17. Article
  18. Medical micro- and nanomotors in the body.Acta pharmaceutica Sinica. B · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yong WangFlexible Printed Electronic Technology Center and School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Yuhuan LiuFlexible Printed Electronic Technology Center and School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Yang LiSchool of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
Dandan XuFlexible Printed Electronic Technology Center and School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Xi PanFlexible Printed Electronic Technology Center and School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Yuduo ChenFlexible Printed Electronic Technology Center and School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
Dekai ZhouKey Laboratory of Microsystems and Microstructures Manufacturing, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Bo WangSchool of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
Huanhuan FengFlexible Printed Electronic Technology Center and School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.ORCID https://orcid.org/0000-0002-1036-1227
Xing MaFlexible Printed Electronic Technology Center and School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.ORCID https://orcid.org/0000-0002-2248-4806

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surface-enhanced Raman spectroscopy (SERS) is a powerful sensing technique capable of capturing ultrasensitive fingerprint signal of analytes with extremely low concentration. However, conventional SERS probes are passive nanoparticles which are usually massively applied for biochemical sensing, lacking controllability and adaptability for precise and targeted sensing at a small scale. Herein, we report a "rod-like" magnetic nanomotor-based SERS probe (MNM-SP) that integrates a mobile and controllable platform of micro-/nanomotors with a SERS sensing technique. The "rod-like" structure is prepared by coating a thin layer of silica onto the self-assembled magnetic nanoparticles. Afterwards, SERS hotspots of silver nanoparticles (AgNPs) are decorated as detecting nanoprobes. The MNM-SPs can be navigated on-demand to avoid obstacles and target sensing sites by the guidance of an external gradient magnetic field. Through applying a rotating magnetic field, the MNM-SPs can actively rotate to efficiently stir and mix surrounding fluid and thus contact with analytes quickly for SERS sensing. Innovatively, we demonstrate the self-cleaning capability of the MNM-SPs which can be used to overcome the contamination problem of traditional single-use SERS probes. Furthermore, the MNM-SPs could precisely approach the targeted single cell and then enter into the cell by endocytosis. It is worth mentioning that by the effective mixing of intracellular biocomponents, much more informative Raman signals with improved signal-to-noise ratio can be captured after active rotation. Therefore, the demonstrated magnetically activated MNM-SPs that are endowed with SERS sensing capability pave way to the future development of smart sensing probes with maneuverability for biochemical analysis at the micro-/nanoscale.

Identifiers

PMID32566931
PMCPMC7293755

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.