ArticleNPJ breast cancer2020
The acute effects of adjuvant radiation and chemotherapy on peripheral blood epigenetic age in early stage breast cancer patients.
Article in NPJ breast cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Who cites it
56 citing papers in PubMed, 77 citations in OpenAlex.
- Exercise and epigenetic ages in older adults with myeloid malignancies.European journal of medical research · 2023Trial
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- p16GeroScience · 2026Article
- Epigenetic indicators of body mass predict survival outcomes in colorectal cancer patients: patient cohort analysis.Genome medicine · 2026Article
- Epigenetic age acceleration measures and chemotoxicity in older adults with early breast cancer.GeroScience · 2026Article
- A targeted epigenetic clock for simultaneous assessment of biological aging and cancer-associated methylation drift.Clinical epigenetics · 2026Article
- Neighborhood deprivation on increasing deficit accumulation in older breast cancer survivors and noncancer control individuals.Journal of the National Cancer Institute · 2026Article
- Multimodal Cancer Therapy and Accelerated Brain Aging: Mechanisms, Biomarkers, and Clinical Consequences.Current oncology (Toronto, Ont.) · 2026Review
- Review
- Epigenetic age acceleration, telomere length, and neurocognitive function in long-term survivors of childhood cancer.Nature communications · 2025Article
- Ferroptosis and cellular senescence -Related Genes in Cervical Cancer: Mechanistic Insights from Multi-Omics and Clinical Sample Analysis.Translational oncology · 2025Article
- Predicting Tolerance to Anthracycline Chemotherapy Using Electrocardiogram-Based Artificial Intelligence in Sarcoma.Mayo Clinic proceedings. Digital health · 2025Article
- DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease.Nature aging · 2025Article
- Controlling treatment toxicity in ovarian cancer to prime the patient for tumor extinction therapy.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic Aging in Pediatric-Onset Multiple Sclerosis.Neurology · 2025Article
- Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers.Cancer medicine · 2025Review
- An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality.bioRxiv : the preprint server for biology · 2025Article
- Association of phenotypic age acceleration with all-cause and cause-specific mortality among U.S. cancer survivors: a retrospective cohort study.BMC cancer · 2025Article
- Transcriptomic markers of biological aging in breast cancer survivors: a longitudinal study.Journal of the National Cancer Institute · 2025Observational
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Survival has increased in early stage breast cancer (BC), and the late effects of treatment persist for decades. Molecular mechanisms underlying the acceleration of age-related diseases after chemotherapy and radiotherapy are poorly understood. We examined epigenetic changes in peripheral whole blood cells in early stage BC patients undergoing surgery followed by adjuvant radiotherapy, or surgery followed by adjuvant chemotherapy and radiotherapy. DNA methylation experiments were performed on whole blood samples collected before and after adjuvant therapy. Methylation profiles were used to estimate four measures of epigenetic age acceleration-intrinsic, extrinsic, phenotypic, and Grim-and cell counts. We found significant increases in extrinsic, phenotypic, and Grim epigenetic age acceleration and in estimated proportions of senescent T lymphocytes from pre- to post-treatment. When examining differential effects by treatment category, most of these increases were significant only in women undergoing radiation alone. Further studies are needed to examine whether these effects are related to the risk of cognitive and functional decline in BC survivors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.