ArticleInternational journal of cardiology. Heart & vasculature2020
Association of comorbidities with clinical outcomes in patients after acute myocardial infarction.
Article in International journal of cardiology. Heart & vasculature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Interleukin-1 blockade in patients with ST-segment elevation myocardial infarction with and without history of coronary artery disease.International journal of cardiology · 2026Trial
- Prior Antiplatelet Exposure and Clinical Outcomes Among Korean Patients With Acute Myocardial Infarction.Journal of the American Heart Association · 2026Article
- Lace Index: Predict the High-Risk of 30-Days Readmission of Patients With Acute Myocardial Infarction: National Health Insurance Claims Data 2011-2020.Journal of evaluation in clinical practice · 2025Article
- Diabetes mellitus risk in post-myocardial infarction patients: FINDRISC versus self-assessment-a cross sectional study.Cardiovascular diabetology · 2025Article
- Door-to-Balloon Time and Clinical Outcome of Patients Presenting with ST-Segment Elevation Myocardial Infarction During on and off Hours: a Single Center Study.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
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- Impact of Comorbid Disease Burden on Clinical Outcomes of Female Acute Myocardial Infarction Patients.Chonnam medical journal · 2023Article
- Myocardial Infarction in Patients with and without COVID-19: Comparisons of Characteristics, Clinical Courses, and Outcomes.The journal of Tehran Heart Center · 2023Article
- Recent highlights on acute myocardial infarction and takotsubo syndrome from the International Journal of Cardiology: Heart & Vasculature.International journal of cardiology. Heart & vasculature · 2022Article
- Predicting Return to Work Following Myocardial Infarction: A Prospective Longitudinal Cohort Study.International journal of environmental research and public health · 2022Article
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- Association Between Early Oral β-Blocker Therapy and In-Hospital Outcomes in Patients With ST-Elevation Myocardial Infarction With Mild-Moderate Heart Failure: Findings From the CCC-ACS Project.Frontiers in cardiovascular medicine · 2022Article
- Short and medium-term outcomes in individuals hospitalized with acute myocardial infarction and multiple chronic conditions: The Worcester heart attack study.Journal of multimorbidity and comorbidityArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultimorbidity becomes more prevalent in patients admitted for acute myocardial infarction (AMI). We investigated the association of an increasing number of comorbidities with the excess risk of in-hospital mortality and other clinically outcomes in hospitalized AMI patients.
methodsIn this population-based cohort study, we analyzed 104'906 admissions for AMI between 2012 and 2018 in Switzerland. We stratified patients based on four different age categories and investigated the association of the number of five common comorbidities (diabetes, chronic kidney-, chronic obstructive pulmonary-, cerebrovascular-, and peripheral artery disease) and risk of in-hospital mortality and other outcomes.
resultsA total of 5'029 admitted AMI patients (4.8%) died during the hospital stay. We found a stepwise increase in mortality risk with each additional comorbidity. Compared to AMI patients with no comorbidity, comorbid patients had a 26% increased risk for mortality (adjusted odds ratio [OR] 1.26, 95% confidence interval [CI] 1.20 to 1.33) with a pronounced association in younger patients. The overall risk for ICU admission, prolonged length of hospital stay (LOS), and 30-day readmission was higher in comorbid patients as compared to those without a comorbidity of interest (ICU: OR 1.19, 95% CI 1.16 to 1.22; LOS: OR 1.84, 95% CI 1.79 to 1.89; Readmission: OR 1.23, 95% CI 1.19 to 1.28), respectively. Again, the association of the numbers of prevalent comorbidities with adverse outcomes was strongest in the youngest patient population.
conclusionsIn patients with AMI, the burden of comorbidities has a strong association with in-hospital mortality and other adverse outcomes - especially in younger patients.
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