Evidence map›Paper›PMID 32566580›Full record

ArticleAnnals of translational medicine2020

Changes in the expression of interleukin-10 in myocardial infarction and its relationship with macrophage activation and cell apoptosis.

Wenqi Yang, Shuming Li, Yang Zhao, Ying Sun, Yuling Huang, Xinying Cao, Cainai Xing, Fang Yang, Wenbo Liu, Xuan Zhao and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
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Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Wenqi YangDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Shuming LiSchool of Basic Medical Sciences, North China University of Science and Technology, Tangshan 065299, China.
Yang ZhaoDepartment of Medical imageology, Hebei North University, Zhangjiakou 075132, China.
Ying SunSchool of Basic Medical Sciences, North China University of Science and Technology, Tangshan 065299, China.
Yuling HuangDepartment of Cardiology, North China University of Science and Technology Affiliated Hospital, Tangshan 065299, China.
Xinying CaoDepartment of Cardiology, North China University of Science and Technology Affiliated Hospital, Tangshan 065299, China.
Cainai XingDepartment of Cardiology, North China University of Science and Technology Affiliated Hospital, Tangshan 065299, China.
Fang YangSchool of Basic Medical Sciences, North China University of Science and Technology, Tangshan 065299, China.
Wenbo LiuDepartment of Cardiology, North China University of Science and Technology Affiliated Hospital, Tangshan 065299, China.
Xuan ZhaoDepartment of Cardiology, North China University of Science and Technology Affiliated Hospital, Tangshan 065299, China.
Xuejing DongDepartment of Cardiology, North China University of Science and Technology Affiliated Hospital, Tangshan 065299, China.
Hua BaiDepartment of Cardiology, North China University of Science and Technology Affiliated Hospital, Tangshan 065299, China.
Xiaoming ShangDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang 050017, China.
North China University of Science and Technology Affiliated Hospital · CNNorth China University of Science and Technology · CNHebei Medical University · CNHebei North University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, the role of interleukin-10 (IL-10) as an anti-inflammatory factor in the occurrence and development of heart disease is still unclear. This study aimed to observe the dynamic changes in the expression of IL-10 in serum and myocardial tissues and to investigate the relationship of IL-10 expression with macrophage activation and cardiomyocyte apoptosis during the occurrence of myocardial infarction (MI).

methodsMice models with MI were prepared by ligating the anterior descending branch of the coronary artery. The animals were classified into the sham operation group (the control group), and the day 1, 7, 14, and 28 MI groups based.

resultsOn days 7 and 14, the cells with positive IL-10 expression were largely distributed in the infarct areas, while cells with positive IL-10 expression were decreased on day 28. Serum IL-10 was significantly positively correlated with IL-10 protein expression in myocardial tissues. Moreover, Bcl-2 and Bax protein expression in myocardial tissues, along with the ratio of Bcl-2/Bax proteins, were gradually elevated with prolonged time of infarction. The expression of arginase protein increased gradually too. There were positive correlations between IL-10 and arginase expressions, and between the expressions of Bcl-2 and Bax proteins.

conclusionsAfter the occurrence of MI, the expression of IL-10 first increased and then decreased in serum and myocardial tissues, with this likely affecting macrophage activation, phenotypic transformation, and the occurrence of cardiomyocyte apoptosis.

Indexed as

cell apoptosisinterleukin-10 (IL-10)macrophageMyocardial infarction (MI)

Identifiers

PMID32566580
PMCPMC7290626
OpenAlexW3031824401

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.