Evidence map›Paper›PMID 32566544›Full record

ArticleCommunications for statistical applications and methods2020

Ranking subjects based on paired compositional data with application to age-related hearing loss subtyping.

Jin Hyun Nam, Aastha Khatiwada, Lois J Matthews, Bradley A Schulte, Judy R Dubno, Dongjun Chung

Abstract read
In one paragraph

Article in Communications for statistical applications and methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jin Hyun NamDepartment of Public Health Sciences, Medical University of South Carolina, USA.
Aastha KhatiwadaDepartment of Public Health Sciences, Medical University of South Carolina, USA.
Lois J MatthewsDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, USA.
Bradley A SchulteDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, USA.
Judy R DubnoDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, USA.
Dongjun ChungDepartment of Public Health Sciences, Medical University of South Carolina, USA.

Funding

SPEECH UNDERSTANDING IN REALISTIC ENVIRONMENTSP50DC000422 · NIDCD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUBNO, JUDY R · 1989 to 2025
$45.3M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Resource CoreP30AR072582 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JAMES C OATES · 2017 to 2026
$8.5M
The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent ModelU01DA045300 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christine Cheng, Dongjun Chung · 2018 to 2026
$6.1M
Statistical Models for Genetic Studies, Using Network and Integrative AnalysisR01GM122078 · NIGMS · OHIO STATE UNIVERSITY · PI CHUNG, DONGJUN · 2016 to 2020
$1.9M
Algorithms for Literature-Guided Multi-Platform Identification of Cancer SubtypesR21CA209848 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHUNG, DONGJUN, KELEMEN, LINDA E · 2016 to 2017
$358k
NCATS NIH HHS UL1 TR001450NCI NIH HHS R21 CA209848NIAMS NIH HHS P30 AR072582NIDA NIH HHS U01 DA045300NIDCD NIH HHS P50 DC000422NIGMS NIH HHS R01 GM122078
6 · The paper itself

Abstract

Analysis approaches for single compositional data are well established; however, effective analysis strategies for paired compositional data remain to be investigated. The current project was motivated by studies of age-related hearing loss (presbyacusis), where subjects are classified into four audiometric phenotypes that need to be ranked within these phenotypes based on their paired compositional data. We address this challenge by formulating this problem as a classification problem and integrating a penalized multinomial logistic regression model with compositional data analysis approaches. We utilize Elastic Net for a penalty function, while considering average, absolute difference, and perturbation operators for compositional data. We applied the proposed approach to the presbyacusis study of 532 subjects with probabilities that each ear of a subject belongs to each of four presbyacusis subtypes. We further investigated the ranking of presbyacusis subjects using the proposed approach based on previous literature. The data analysis results indicate that the proposed approach is effective for ranking subjects based on paired compositional data.

Indexed as

compositionelastic netpenalized logistic regressionpresbyacusis

Identifiers

PMID32566544
PMCPMC7304553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.