ArticleCase reports in psychiatry2020
A Case Report on an Atypical Presentation of the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) in a War Veteran with Bipolar Disorder and PTSD.
Article in Case reports in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- The Application of Deep Brain Stimulation in the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity.Journal of movement disorders · 2025Article
- The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity: A Scoping Review.Alpha psychiatry · 2024Article
- Emergency medicine research in the Philippines: A scoping review.Journal of the American College of Emergency Physicians open · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLithium is still the first-line agent for bipolar disorder. Despite common knowledge on monitoring lithium levels to prevent toxicity, it still occurs at varying degrees. Here we present a rare sequela of lithium toxicity, the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT).
conclusionSILENT has been coined after reports of persistent neurologic deficits were seen in patients who experienced lithium toxicity more than 2 months after cessation of lithium. Chronic lithium therapy predisposes to gradual accumulation of lithium in the brain. Demyelination is the typically reported feature of SILENT. It can also leave the patient in a persistent encephalopathic state. Chronic lithium toxicity from failure of monitoring puts patients on lithium therapy at risk.
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