ArticleOxidative medicine and cellular longevity2020
Placentae for Low Birth Weight Piglets Are Vulnerable to Oxidative Stress, Mitochondrial Dysfunction, and Impaired Angiogenesis.
Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Analysis of the evolution of placental oxidative stress research from a bibliometric perspective.Frontiers in pharmacology · 2024Pooled it
- Effects of Chlorogenic Acid-RichAntioxidants (Basel, Switzerland) · 2026Article
- The Role of Branched-Chain Amino Acids in Nutrient Allocation of the Porcine Placenta: A Review.Animals : an open access journal from MDPI · 2026Review
- Excess backfat deposition and restricted feeding in gestating sows: An overview of mechanisms compromising their health and performance, and regulatory effects of functional dietary fibers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Effects of nicotinamide riboside supplementation during late gestation and lactation on sow performance, milk metabolome, and gut microbiome.Journal of animal science and biotechnology · 2026Article
- Effect ofTranslational animal science · 2026Article
- MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice.International journal of molecular medicine · 2026Article
- Variations in Diacron-Reactive Oxygen Metabolites and Biological Antioxidant Potential Across Reproductive Phases and Parities in Sows Reared Under Different Production Systems.Animals : an open access journal from MDPI · 2025Article
- Utero-placental adaptations in response to intrauterine growth restriction in swine.Domestic animal endocrinology · 2025Review
- Dynamic changes in peripheral blood CD4+ T cell subsets are associated with litter performance in primiparous gestating sows.Journal of animal science · 2025Article
- Effects of dietary oyster peptide supplement on litter performance, immunological response of sows and growth performance of piglets.Frontiers in veterinary science · 2025Article
- Identification and characterization of signature genes related to fetoplacental vascular endothelial cell programming in gestational diabetes mellitus using bioinformatics analysis.Frontiers in genetics · 2025Article
- Prenatal ozone exposure is associated with children overweight and obesity: Evidence from the Shanghai Maternal-Child Pairs Cohort.Eco-Environment & Health · 2024Article
- Article
- Genetic predicted causal inferences between antioxidants and birth weight.Journal of clinical biochemistry and nutrition · 2024Article
- FGR-associated placental insufficiency and capillary angiogenesis involves disruptions in human placental miRNAs and mRNAs.Heliyon · 2024Article
- Maternal Supplementation with Ornithine Promotes Placental Angiogenesis and Improves Intestinal Development of Suckling Piglets.Animals : an open access journal from MDPI · 2024Article
- Exploring characteristics of placental transcriptome and cord serum metabolome associated with low birth weight in Kele pigs.Tropical animal health and production · 2023Article
- Dietary adenosine supplementation improves placental angiogenesis in IUGR piglets by up-regulating adenosine A2a receptor.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Placental Malfunction, Fetal Survival and Development Caused by Sow Metabolic Disorder: The Impact of Maternal Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrauterine growth restriction (IUGR) is associated with fetal mortality and morbidity. One of the most common causes of IUGR is placental insufficiency, including placental vascular defects, and mitochondrial dysfunction. In addition, a high level of oxidative stress induces placental vascular lesions. Here, we evaluated the oxidative stress status, mitochondrial function, angiogenesis, and nutrient transporters in placentae of piglets with different birth weights: <500 g (L), 500-600 g (LM), 600-700 g (M), and >700 g (H). Results showed that placentae from the L group had higher oxidative damage, lower adenosine triphosphate and citrate synthase levels, and lower vascular density, compared to those from the other groups. Protein expression of angiogenic markers, including vascular endothelial cadherin, vascular endothelial growth factor A, and platelet endothelial cell adhesion molecule-1, was the lowest in the L group placentae compared to the other groups. In addition, the protein levels of glucose transporters GLUT1 and GLUT3 were downregulated in the L group, compared to the other groups. Furthermore, oxidative stress induced by H
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